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Metabolism and disposition of JNJ-10450232 (NTM-006) in rats, dogs, monkeys and humans.
Lim HK, Chen J, Lam W, Gong Y, Leclercq L, Silva J, Salter R, Berwaerts J, Gelotte CK, Vakil AM, Eichenbaum GE, Kuffner EK, Flores CM. Lim HK, et al. Among authors: kuffner ek. Regul Toxicol Pharmacol. 2023 Mar 16:105379. doi: 10.1016/j.yrtph.2023.105379. Online ahead of print. Regul Toxicol Pharmacol. 2023. PMID: 36931586 Free article.
Preclinical safety assessment of JNJ-10450232 (NTM-006), a structural analog of acetaminophen, that does not cause hepatotoxicity at supratherapeutic doses.
Zhou J, De Jonghe S, Codd EE, Weiner S, Gallacher D, Stahle P, Kelley MF, Kuffner EK, Flores CM, Eichenbaum GE. Zhou J, et al. Among authors: kuffner ek. Regul Toxicol Pharmacol. 2023 Jan 4:105334. doi: 10.1016/j.yrtph.2023.105334. Online ahead of print. Regul Toxicol Pharmacol. 2023. PMID: 36608923 Free article.
JNJ-10450232 (NTM-006), A novel non-opioid with structural similarities to acetaminophen, produces relatively long-lasting analgesia after a single dose in patients undergoing 3rd molar extraction.
Gelotte CK, Vakil AM, Zimmerman BA, Zannikos P, Mishra R, Eichenbaum G, Kuffner EK, Flores CM. Gelotte CK, et al. Among authors: kuffner ek. Regul Toxicol Pharmacol. 2023 Aug 23:105480. doi: 10.1016/j.yrtph.2023.105480. Online ahead of print. Regul Toxicol Pharmacol. 2023. PMID: 37625518 Free article.
First-in-human study to evaluate the safety, tolerability and pharmacokinetics of a novel analgesic and antipyretic drug with structural similarity to acetaminophen.
Gelotte CK, Vakil AM, Berwaerts J, Zimmerman BA, Eichenbaum GE, Flores CM, Kuffner EK. Gelotte CK, et al. Among authors: kuffner ek. Regul Toxicol Pharmacol. 2022 Oct;134:105236. doi: 10.1016/j.yrtph.2022.105236. Epub 2022 Aug 5. Regul Toxicol Pharmacol. 2022. PMID: 35934140 Clinical Trial.
16 results