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Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity.
Doyle SR, Bourguinat C, Nana-Djeunga HC, Kengne-Ouafo JA, Pion SDS, Bopda J, Kamgno J, Wanji S, Che H, Kuesel AC, Walker M, Basáñez MG, Boakye DA, Osei-Atweneboana MY, Boussinesq M, Prichard RK, Grant WN. Doyle SR, et al. Among authors: kuesel ac. PLoS Negl Trop Dis. 2017 Jul 26;11(7):e0005816. doi: 10.1371/journal.pntd.0005816. eCollection 2017 Jul. PLoS Negl Trop Dis. 2017. PMID: 28746337 Free PMC article.
How Can Onchocerciasis Elimination in Africa Be Accelerated? Modeling the Impact of Increased Ivermectin Treatment Frequency and Complementary Vector Control.
Verver S, Walker M, Kim YE, Fobi G, Tekle AH, Zouré HGM, Wanji S, Boakye DA, Kuesel AC, de Vlas SJ, Boussinesq M, Basáñez MG, Stolk WA. Verver S, et al. Among authors: kuesel ac. Clin Infect Dis. 2018 Jun 1;66(suppl_4):S267-S274. doi: 10.1093/cid/cix1137. Clin Infect Dis. 2018. PMID: 29860291 Free PMC article.
Assessing Onchocerca volvulus Intensity of Infection and Genetic Diversity Using Mitochondrial Genome Sequencing of Single Microfilariae Obtained before and after Ivermectin Treatment.
Hedtke SM, Choi YJ, Kode A, Chalasani GC, Sirwani N, Jada SR, Hotterbeekx A, Mandro M, Siewe Fodjo JN, Amambo GN, Abong RA, Wanji S, Kuesel AC, Colebunders R, Mitreva M, Grant WN. Hedtke SM, et al. Among authors: kuesel ac. Pathogens. 2023 Jul 24;12(7):971. doi: 10.3390/pathogens12070971. Pathogens. 2023. PMID: 37513818 Free PMC article.
Procedure for Handling and Storage of Onchocerca volvulus Microfilariae Obtained from Skin Snips for Downstream Genetic Work.
Hedtke SM, Kode A, Ukety TO, Mande JL, Abhafule GM, Raciu AA, Uvon CB, Jada SR, Hotterbeekx A, Siewe Fodjo JN, Mitreva M, Sebit W, Colebunders R, Grant WN, Kuesel AC. Hedtke SM, et al. Among authors: kuesel ac. Trop Med Infect Dis. 2023 Sep 12;8(9):445. doi: 10.3390/tropicalmed8090445. Trop Med Infect Dis. 2023. PMID: 37755906 Free PMC article.
46 results