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Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation.
Erfinanda L, Zou L, Gutbier B, Kneller L, Weidenfeld S, Michalick L, Lei D, Reppe K, Teixeira Alves LG, Schneider B, Zhang Q, Li C, Fatykhova D, Schneider P, Liedtke W, Sohara E, Mitchell TJ, Gruber AD, Hocke A, Hippenstiel S, Suttorp N, Olschewski A, Mall MA, Witzenrath M, Kuebler WM. Erfinanda L, et al. Among authors: kuebler wm. Sci Transl Med. 2022 Dec 7;14(674):eabg8577. doi: 10.1126/scitranslmed.abg8577. Epub 2022 Dec 7. Sci Transl Med. 2022. PMID: 36475904
Angiotensin-(1-7) protects from experimental acute lung injury.
Klein N, Gembardt F, Supé S, Kaestle SM, Nickles H, Erfinanda L, Lei X, Yin J, Wang L, Mertens M, Szaszi K, Walther T, Kuebler WM. Klein N, et al. Among authors: kuebler wm. Crit Care Med. 2013 Nov;41(11):e334-43. doi: 10.1097/CCM.0b013e31828a6688. Crit Care Med. 2013. PMID: 23949470
Functional transient receptor potential vanilloid 1 and transient receptor potential vanilloid 4 channels along different segments of the renal vasculature.
Chen L, Kaßmann M, Sendeski M, Tsvetkov D, Marko L, Michalick L, Riehle M, Liedtke WB, Kuebler WM, Harteneck C, Tepel M, Patzak A, Gollasch M. Chen L, et al. Among authors: kuebler wm. Acta Physiol (Oxf). 2015 Feb;213(2):481-91. doi: 10.1111/apha.12355. Epub 2014 Aug 21. Acta Physiol (Oxf). 2015. PMID: 25069877
TRPV4 Is Required for Hypoxic Pulmonary Vasoconstriction.
Goldenberg NM, Wang L, Ranke H, Liedtke W, Tabuchi A, Kuebler WM. Goldenberg NM, et al. Among authors: kuebler wm. Anesthesiology. 2015 Jun;122(6):1338-48. doi: 10.1097/ALN.0000000000000647. Anesthesiology. 2015. PMID: 25815455 Free article.
CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction.
Tabeling C, Yu H, Wang L, Ranke H, Goldenberg NM, Zabini D, Noe E, Krauszman A, Gutbier B, Yin J, Schaefer M, Arenz C, Hocke AC, Suttorp N, Proia RL, Witzenrath M, Kuebler WM. Tabeling C, et al. Among authors: kuebler wm. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1614-23. doi: 10.1073/pnas.1421190112. Epub 2015 Mar 17. Proc Natl Acad Sci U S A. 2015. PMID: 25829545 Free PMC article.
Role of Transient Receptor Potential Vanilloid 4 in Neutrophil Activation and Acute Lung Injury.
Yin J, Michalick L, Tang C, Tabuchi A, Goldenberg N, Dan Q, Awwad K, Wang L, Erfinanda L, Nouailles G, Witzenrath M, Vogelzang A, Lv L, Lee WL, Zhang H, Rotstein O, Kapus A, Szaszi K, Fleming I, Liedtke WB, Kuppe H, Kuebler WM. Yin J, et al. Among authors: kuebler wm. Am J Respir Cell Mol Biol. 2016 Mar;54(3):370-83. doi: 10.1165/rcmb.2014-0225OC. Am J Respir Cell Mol Biol. 2016. PMID: 26222277
Spleen tyrosine kinase inhibition blocks airway constriction and protects from Th2-induced airway inflammation and remodeling.
Tabeling C, Herbert J, Hocke AC, Lamb DJ, Wollin SL, Erb KJ, Boiarina E, Movassagh H, Scheffel J, Doehn JM, Hippenstiel S, Maurer M, Gounni AS, Kuebler WM, Suttorp N, Witzenrath M. Tabeling C, et al. Among authors: kuebler wm. Allergy. 2017 Jul;72(7):1061-1072. doi: 10.1111/all.13101. Epub 2017 Jan 12. Allergy. 2017. PMID: 27906453
305 results