Kudolo M - Search Results

1

Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3.

Ansideri F, Macedo JT, Eitel M, El-Gokha A, Zinad DS, Scarpellini C, Kudolo M, Schollmeyer D, Boeckler FM, Blaum BS, Laufer SA, Koch P. Ansideri F, et al. Among authors: kudolo m. ACS Omega. 2018 Jul 31;3(7):7809-7831. doi: 10.1021/acsomega.8b00668. Epub 2018 Jul 12. ACS Omega. 2018. PMID: 30087925 Free PMC article.

2

Pyridinylimidazoles as dual glycogen synthase kinase 3β/p38α mitogen-activated protein kinase inhibitors.

Heider F, Ansideri F, Tesch R, Pantsar T, Haun U, Döring E, Kudolo M, Poso A, Albrecht W, Laufer SA, Koch P. Heider F, et al. Among authors: kudolo m. Eur J Med Chem. 2019 Aug 1;175:309-329. doi: 10.1016/j.ejmech.2019.04.035. Epub 2019 Apr 24. Eur J Med Chem. 2019. PMID: 31096153

3

Design, Synthesis and Biological Evaluation of 7-Chloro-9H-pyrimido[4,5-b]indole-based Glycogen Synthase Kinase-3β Inhibitors.

Andreev S, Pantsar T, Ansideri F, Kudolo M, Forster M, Schollmeyer D, Laufer SA, Koch P. Andreev S, et al. Among authors: kudolo m. Molecules. 2019 Jun 25;24(12):2331. doi: 10.3390/molecules24122331. Molecules. 2019. PMID: 31242571 Free PMC article.

4

Pyridinylimidazoles as GSK3β Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks.

Heider F, Pantsar T, Kudolo M, Ansideri F, De Simone A, Pruccoli L, Schneider T, Goettert MI, Tarozzi A, Andrisano V, Laufer SA, Koch P. Heider F, et al. Among authors: kudolo m. ACS Med Chem Lett. 2019 Aug 26;10(10):1407-1414. doi: 10.1021/acsmedchemlett.9b00177. eCollection 2019 Oct 10. ACS Med Chem Lett. 2019. PMID: 31620226 Free PMC article.

5

Discovery and Evaluation of Enantiopure 9H-pyrimido[4,5-b]indoles as Nanomolar GSK-3β Inhibitors with Improved Metabolic Stability.

Andreev S, Pantsar T, El-Gokha A, Ansideri F, Kudolo M, Anton DB, Sita G, Romasco J, Geibel C, Lämmerhofer M, Goettert MI, Tarozzi A, Laufer SA, Koch P. Andreev S, et al. Among authors: kudolo m. Int J Mol Sci. 2020 Oct 22;21(21):7823. doi: 10.3390/ijms21217823. Int J Mol Sci. 2020. PMID: 33105671 Free PMC article.

6

Decisive role of water and protein dynamics in residence time of p38α MAP kinase inhibitors.

Pantsar T, Kaiser PD, Kudolo M, Forster M, Rothbauer U, Laufer SA. Pantsar T, et al. Among authors: kudolo m. Nat Commun. 2022 Jan 28;13(1):569. doi: 10.1038/s41467-022-28164-4. Nat Commun. 2022. PMID: 35091547 Free PMC article.

7

Pharmacokinetic Optimization of Small Molecule Janus Kinase 3 Inhibitors to Target Immune Cells.

Laux J, Forster M, Riexinger L, Schwamborn A, Guezguez J, Pokoj C, Kudolo M, Berger LM, Knapp S, Schollmeyer D, Guse J, Burnet M, Laufer SA. Laux J, et al. Among authors: kudolo m. ACS Pharmacol Transl Sci. 2022 Jul 14;5(8):573-602. doi: 10.1021/acsptsci.2c00054. eCollection 2022 Aug 12. ACS Pharmacol Transl Sci. 2022. PMID: 35983274 Free PMC article.

8

From 2-Alkylsulfanylimidazoles to 2-Alkylimidazoles: An Approach towards Metabolically More Stable p38α MAP Kinase Inhibitors.

Heider F, Haun U, Döring E, Kudolo M, Sessler C, Albrecht W, Laufer S, Koch P. Heider F, et al. Among authors: kudolo m. Molecules. 2017 Oct 14;22(10):1729. doi: 10.3390/molecules22101729. Molecules. 2017. PMID: 29036906 Free PMC article.

9

Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors.

Röhm S, Berger BT, Schröder M, Chaikuad A, Winkel R, Hekking KFW, Benningshof JJC, Müller G, Tesch R, Kudolo M, Forster M, Laufer S, Knapp S. Röhm S, et al. Among authors: kudolo m. J Med Chem. 2019 Dec 12;62(23):10757-10782. doi: 10.1021/acs.jmedchem.9b01227. Epub 2019 Nov 26. J Med Chem. 2019. PMID: 31702918

10

Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation.

Astolfi A, Kudolo M, Brea J, Manni G, Manfroni G, Palazzotti D, Sabatini S, Cecchetti F, Felicetti T, Cannalire R, Massari S, Tabarrini O, Loza MI, Fallarino F, Cecchetti V, Laufer SA, Barreca ML. Astolfi A, et al. Among authors: kudolo m. Eur J Med Chem. 2019 Nov 15;182:111624. doi: 10.1016/j.ejmech.2019.111624. Epub 2019 Aug 16. Eur J Med Chem. 2019. PMID: 31445234

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