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7-Azaindole, 2,7-diazaindole, and 1H-pyrazole as core structures for novel anticancer agents with potential chemosensitizing properties.
Gorecki L, Muthna D, Merdita S, Andrs M, Kucera T, Havelek R, Muckova L, Kobrlova T, Soukup J, Krupa P, Prchal L, Soukup O, Roh J, Rezacova M, Korabecny J. Gorecki L, et al. Among authors: kucera t. Eur J Med Chem. 2022 Oct 5;240:114580. doi: 10.1016/j.ejmech.2022.114580. Epub 2022 Jun 30. Eur J Med Chem. 2022. PMID: 35793579
Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy.
Mezeiova E, Korabecny J, Sepsova V, Hrabinova M, Jost P, Muckova L, Kucera T, Dolezal R, Misik J, Spilovska K, Pham NL, Pokrievkova L, Roh J, Jun D, Soukup O, Kaping D, Kuca K. Mezeiova E, et al. Among authors: kucera t. Molecules. 2017 Jul 28;22(8):1265. doi: 10.3390/molecules22081265. Molecules. 2017. PMID: 28788095 Free PMC article.
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.
Hepnarova V, Korabecny J, Matouskova L, Jost P, Muckova L, Hrabinova M, Vykoukalova N, Kerhartova M, Kucera T, Dolezal R, Nepovimova E, Spilovska K, Mezeiova E, Pham NL, Jun D, Staud F, Kaping D, Kuca K, Soukup O. Hepnarova V, et al. Among authors: kucera t. Eur J Med Chem. 2018 Apr 25;150:292-306. doi: 10.1016/j.ejmech.2018.02.083. Epub 2018 Mar 2. Eur J Med Chem. 2018. PMID: 29533874
Oxime K203: a drug candidate for the treatment of tabun intoxication.
Gorecki L, Soukup O, Kucera T, Malinak D, Jun D, Kuca K, Musilek K, Korabecny J. Gorecki L, et al. Among authors: kucera t. Arch Toxicol. 2019 Mar;93(3):673-691. doi: 10.1007/s00204-018-2377-7. Epub 2018 Dec 18. Arch Toxicol. 2019. PMID: 30564897
In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier.
Chlebek J, Korábečný J, Doležal R, Štěpánková Š, Pérez DI, Hošťálková A, Opletal L, Cahlíková L, Macáková K, Kučera T, Hrabinová M, Jun D. Chlebek J, et al. Among authors: kucera t. Molecules. 2019 Apr 5;24(7):1340. doi: 10.3390/molecules24071340. Molecules. 2019. PMID: 30959739 Free PMC article.
165 results