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827 results

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Page 1
Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models.
Matsukawa T, Yagi T, Uchida T, Sakai M, Mitsushima M, Naganuma T, Yano H, Inaba Y, Inoue H, Yanagida K, Uematsu M, Nakao K, Nakao H, Aiba A, Nagashima Y, Kubota T, Kubota N, Izumida Y, Yahagi N, Unoki-Kubota H, Kaburagi Y, Asahara SI, Kido Y, Shindou H, Itoh M, Ogawa Y, Minami S, Terauchi Y, Tobe K, Ueki K, Kasuga M, Matsumoto M. Matsukawa T, et al. Among authors: kubota n, kubota t. JCI Insight. 2023 Sep 8;8(17):e161282. doi: 10.1172/jci.insight.161282. JCI Insight. 2023. PMID: 37681411 Free PMC article.
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.
Kubota N, Tobe K, Terauchi Y, Eto K, Yamauchi T, Suzuki R, Tsubamoto Y, Komeda K, Nakano R, Miki H, Satoh S, Sekihara H, Sciacchitano S, Lesniak M, Aizawa S, Nagai R, Kimura S, Akanuma Y, Taylor SI, Kadowaki T. Kubota N, et al. Diabetes. 2000 Nov;49(11):1880-9. doi: 10.2337/diabetes.49.11.1880. Diabetes. 2000. PMID: 11078455
The role of PPARgamma as a thrifty gene both in mice and humans.
Hara K, Kubota N, Tobe K, Terauchi Y, Miki H, Komeda K, Tamemoto H, Yamauchi T, Hagura R, Ito C, Akanuma Y, Kadowaki T. Hara K, et al. Among authors: kubota n. Br J Nutr. 2000 Dec;84 Suppl 2:S235-9. doi: 10.1079/096582197388608. Br J Nutr. 2000. PMID: 11242476
Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice.
Tsuji Y, Kaburagi Y, Terauchi Y, Satoh S, Kubota N, Tamemoto H, Kraemer FB, Sekihara H, Aizawa S, Akanuma Y, Tobe K, Kimura S, Kadowaki T. Tsuji Y, et al. Among authors: kubota n. Diabetes. 2001 Jun;50(6):1455-63. doi: 10.2337/diabetes.50.6.1455. Diabetes. 2001. PMID: 11375348
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.
Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T. Yamauchi T, et al. Among authors: kubota n. Nat Med. 2001 Aug;7(8):941-6. doi: 10.1038/90984. Nat Med. 2001. PMID: 11479627
The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance.
Yamauchi T, Kamon J, Waki H, Murakami K, Motojima K, Komeda K, Ide T, Kubota N, Terauchi Y, Tobe K, Miki H, Tsuchida A, Akanuma Y, Nagai R, Kimura S, Kadowaki T. Yamauchi T, et al. Among authors: kubota n. J Biol Chem. 2001 Nov 2;276(44):41245-54. doi: 10.1074/jbc.M103241200. Epub 2001 Aug 31. J Biol Chem. 2001. PMID: 11533050 Free article.
827 results