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Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease.
Czarnota-Łydka K, Sudoł-Tałaj S, Kucwaj-Brysz K, Kurczab R, Satała G, de Candia M, Samarelli F, Altomare CD, Carocci A, Barbarossa A, Żesławska E, Głuch-Lutwin M, Mordyl B, Kubacka M, Wilczyńska-Zawal N, Jastrzębska-Więsek M, Partyka A, Khan N, Więcek M, Nitek W, Honkisz-Orzechowska E, Latacz G, Wesołowska A, Carrieri A, Handzlik J. Czarnota-Łydka K, et al. Among authors: kubacka m. Eur J Med Chem. 2023 Nov 5;259:115695. doi: 10.1016/j.ejmech.2023.115695. Epub 2023 Jul 30. Eur J Med Chem. 2023. PMID: 37567058 Free article.
Pharmacological evaluation of the anxiolytic-like effects of EMD 386088, a partial 5-HT6 receptor agonist, in the rat elevated plus-maze and Vogel conflict tests.
Jastrzębska-Więsek M, Siwek A, Partyka A, Kubacka M, Mogilski S, Wasik A, Kołaczkowski M, Wesołowska A. Jastrzębska-Więsek M, et al. Among authors: kubacka m. Neuropharmacology. 2014 Oct;85:253-62. doi: 10.1016/j.neuropharm.2014.05.036. Epub 2014 Jun 4. Neuropharmacology. 2014. PMID: 24905144
Antidepressant-like activity of aroxyalkyl derivatives of 2-methoxyphenylpiperazine and evidence for the involvement of serotonin receptor subtypes in their mechanism of action.
Kubacka M, Mogilski S, Bednarski M, Nowiński L, Dudek M, Żmudzka E, Siwek A, Waszkielewicz AM, Marona H, Satała G, Bojarski A, Filipek B, Pytka K. Kubacka M, et al. Pharmacol Biochem Behav. 2016 Feb;141:28-41. doi: 10.1016/j.pbb.2015.11.013. Epub 2015 Dec 2. Pharmacol Biochem Behav. 2016. PMID: 26647362
Aryl-1,3,5-triazine ligands of histamine H4 receptor attenuate inflammatory and nociceptive response to carrageen, zymosan and lipopolysaccharide.
Mogilski S, Kubacka M, Łażewska D, Więcek M, Głuch-Lutwin M, Tyszka-Czochara M, Bukowska-Strakova K, Filipek B, Kieć-Kononowicz K. Mogilski S, et al. Among authors: kubacka m. Inflamm Res. 2017 Jan;66(1):79-95. doi: 10.1007/s00011-016-0997-z. Epub 2016 Oct 20. Inflamm Res. 2017. PMID: 27766379 Free PMC article.
Biphenyloxy-alkyl-piperidine and azepane derivatives as histamine H3 receptor ligands.
Łażewska D, Kaleta M, Schwed JS, Karcz T, Mogilski S, Latacz G, Olejarz A, Siwek A, Kubacka M, Lubelska A, Honkisz E, Handzlik J, Filipek B, Stark H, Kieć-Kononowicz K. Łażewska D, et al. Among authors: kubacka m. Bioorg Med Chem. 2017 Oct 15;25(20):5341-5354. doi: 10.1016/j.bmc.2017.07.058. Epub 2017 Jul 29. Bioorg Med Chem. 2017. PMID: 28797771
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