Ku TC - Search Results

1

Illuminating the norepinephrine transporter: fluorescent probes based on nisoxetine and talopram.

Camacho-Hernandez GA, Casiraghi A, Rudin D, Luethi D, Ku TC, Guthrie DA, Straniero V, Valoti E, Schütz GJ, Sitte HH, Newman AH. Camacho-Hernandez GA, et al. Among authors: ku tc. RSC Med Chem. 2021 Jun 9;12(7):1174-1186. doi: 10.1039/d1md00072a. eCollection 2021 Jul 21. RSC Med Chem. 2021. PMID: 34355183 Free PMC article.

2

Structure-Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability.

Slack RD, Ku TC, Cao J, Giancola JB, Bonifazi A, Loland CJ, Gadiano A, Lam J, Rais R, Slusher BS, Coggiano M, Tanda G, Newman AH. Slack RD, et al. Among authors: ku tc. J Med Chem. 2020 Mar 12;63(5):2343-2357. doi: 10.1021/acs.jmedchem.9b01188. Epub 2019 Nov 14. J Med Chem. 2020. PMID: 31661268 Free PMC article.

3

Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter.

Guthrie DA, Klein Herenbrink C, Lycas MD, Ku T, Bonifazi A, DeVree BT, Mathiasen S, Javitch JA, Grimm JB, Lavis L, Gether U, Newman AH. Guthrie DA, et al. ACS Chem Neurosci. 2020 Oct 21;11(20):3288-3300. doi: 10.1021/acschemneuro.0c00397. Epub 2020 Oct 1. ACS Chem Neurosci. 2020. PMID: 32926777 Free PMC article.

4

Structure-activity relationships for a series of (Bis(4-fluorophenyl)methyl)sulfinylethyl-aminopiperidines and -piperidine amines at the dopamine transporter: Bioisosteric replacement of the piperazine improves metabolic stability.

Giancola JB, Bonifazi A, Cao J, Ku T, Haraczy AJ, Lam J, Rais R, Coggiano MA, Tanda G, Newman AH. Giancola JB, et al. Eur J Med Chem. 2020 Dec 15;208:112674. doi: 10.1016/j.ejmech.2020.112674. Epub 2020 Aug 9. Eur J Med Chem. 2020. PMID: 32947229 Free PMC article.

5

New Drugs, Old Targets: Tweaking the Dopamine System to Treat Psychostimulant Use Disorders.

Newman AH, Ku T, Jordan CJ, Bonifazi A, Xi ZX. Newman AH, et al. Annu Rev Pharmacol Toxicol. 2021 Jan 6;61:609-628. doi: 10.1146/annurev-pharmtox-030220-124205. Annu Rev Pharmacol Toxicol. 2021. PMID: 33411583 Free PMC article.

6

Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters.

Bhat S, Guthrie DA, Kasture A, El-Kasaby A, Cao J, Bonifazi A, Ku T, Giancola JB, Hummel T, Freissmuth M, Newman AH. Bhat S, et al. ACS Pharmacol Transl Sci. 2020 Aug 28;4(2):503-516. doi: 10.1021/acsptsci.0c00102. eCollection 2021 Apr 9. ACS Pharmacol Transl Sci. 2020. PMID: 33860180 Free PMC article.

7

Toward Reducing hERG Affinities for DAT Inhibitors with a Combined Machine Learning and Molecular Modeling Approach.

Lee KH, Fant AD, Guo J, Guan A, Jung J, Kudaibergenova M, Miranda WE, Ku T, Cao J, Wacker S, Duff HJ, Newman AH, Noskov SY, Shi L. Lee KH, et al. J Chem Inf Model. 2021 Sep 27;61(9):4266-4279. doi: 10.1021/acs.jcim.1c00856. Epub 2021 Aug 21. J Chem Inf Model. 2021. PMID: 34420294 Free PMC article.

8

Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile.

Okorom AV, Camacho-Hernandez GA, Salomon K, Lee KH, Ku TC, Cao J, Won SJ, Friedman J, Lam J, Paule J, Rais R, Klein B, Xi ZX, Shi L, Loland CJ, Newman AH. Okorom AV, et al. Among authors: ku tc. J Med Chem. 2024 Jan 11;67(1):709-727. doi: 10.1021/acs.jmedchem.3c02037. Epub 2023 Dec 20. J Med Chem. 2024. PMID: 38117239

9

Series of (([1,1'-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity.

Ku TC, Cao J, Won SJ, Guo J, Camacho-Hernandez GA, Okorom AV, Salomon KW, Lee KH, Loland CJ, Duff HJ, Shi L, Newman AH. Ku TC, et al. ACS Pharmacol Transl Sci. 2024 Jan 5;7(2):515-532. doi: 10.1021/acsptsci.3c00322. eCollection 2024 Feb 9. ACS Pharmacol Transl Sci. 2024. PMID: 38357284

10

Synthesis of distal and proximal fleximer base analogues and evaluation in the nucleocapsid protein of HIV-1.

Ku T, Lopresti N, Shirley M, Mori M, Marchant J, Heng X, Botta M, Summers MF, Seley-Radtke KL. Ku T, et al. Bioorg Med Chem. 2019 Jul 1;27(13):2883-2892. doi: 10.1016/j.bmc.2019.05.019. Epub 2019 May 15. Bioorg Med Chem. 2019. PMID: 31126822 Free PMC article.

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