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Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2.
Caplan T, Lorente-Macías Á, Stogios PJ, Evdokimova E, Hyde S, Wellington MA, Liston S, Iyer KR, Puumala E, Shekhar-Guturja T, Robbins N, Savchenko A, Krysan DJ, Whitesell L, Zuercher WJ, Cowen LE. Caplan T, et al. Among authors: krysan dj. Cell Chem Biol. 2020 Mar 19;27(3):269-282.e5. doi: 10.1016/j.chembiol.2019.12.008. Epub 2020 Jan 7. Cell Chem Biol. 2020. PMID: 31924499 Free PMC article.
A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis.
Butts A, DiDone L, Koselny K, Baxter BK, Chabrier-Rosello Y, Wellington M, Krysan DJ. Butts A, et al. Among authors: krysan dj. Eukaryot Cell. 2013 Feb;12(2):278-87. doi: 10.1128/EC.00314-12. Epub 2012 Dec 14. Eukaryot Cell. 2013. PMID: 23243064 Free PMC article.
Candida albicans triggers NLRP3-mediated pyroptosis in macrophages.
Wellington M, Koselny K, Sutterwala FS, Krysan DJ. Wellington M, et al. Among authors: krysan dj. Eukaryot Cell. 2014 Feb;13(2):329-40. doi: 10.1128/EC.00336-13. Epub 2013 Dec 27. Eukaryot Cell. 2014. PMID: 24376002 Free PMC article.
Catching fire: Candida albicans, macrophages, and pyroptosis.
Krysan DJ, Sutterwala FS, Wellington M. Krysan DJ, et al. PLoS Pathog. 2014 Jun 26;10(6):e1004139. doi: 10.1371/journal.ppat.1004139. eCollection 2014 Jun. PLoS Pathog. 2014. PMID: 24967821 Free PMC article. No abstract available.
The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis.
Koselny K, Green J, DiDone L, Halterman JP, Fothergill AW, Wiederhold NP, Patterson TF, Cushion MT, Rappelye C, Wellington M, Krysan DJ. Koselny K, et al. Among authors: krysan dj. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7115-7127. doi: 10.1128/AAC.01061-16. Print 2016 Dec. Antimicrob Agents Chemother. 2016. PMID: 27645246 Free PMC article.
The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation.
Xie JL, Qin L, Miao Z, Grys BT, Diaz JC, Ting K, Krieger JR, Tong J, Tan K, Leach MD, Ketela T, Moran MF, Krysan DJ, Boone C, Andrews BJ, Selmecki A, Ho Wong K, Robbins N, Cowen LE. Xie JL, et al. Among authors: krysan dj. Nat Commun. 2017 Sep 11;8(1):499. doi: 10.1038/s41467-017-00547-y. Nat Commun. 2017. PMID: 28894103 Free PMC article.
113 results