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TPC2 rescues lysosomal storage in mucolipidosis type IV, Niemann-Pick type C1, and Batten disease.
Scotto Rosato A, Krogsaeter EK, Jaślan D, Abrahamian C, Montefusco S, Soldati C, Spix B, Pizzo MT, Grieco G, Böck J, Wyatt A, Wünkhaus D, Passon M, Stieglitz M, Keller M, Hermey G, Markmann S, Gruber-Schoffnegger D, Cotman S, Johannes L, Crusius D, Boehm U, Wahl-Schott C, Biel M, Bracher F, De Leonibus E, Polishchuk E, Medina DL, Paquet D, Grimm C. Scotto Rosato A, et al. Among authors: krogsaeter ek. EMBO Mol Med. 2022 Sep 7;14(9):e15377. doi: 10.15252/emmm.202115377. Epub 2022 Aug 5. EMBO Mol Med. 2022. PMID: 35929194 Free PMC article.
The protein interaction networks of mucolipins and two-pore channels.
Krogsaeter EK, Biel M, Wahl-Schott C, Grimm C. Krogsaeter EK, et al. Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1111-1123. doi: 10.1016/j.bbamcr.2018.10.020. Epub 2018 Nov 2. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 30395881 Free PMC article.
Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells.
Plesch E, Chen CC, Butz E, Scotto Rosato A, Krogsaeter EK, Yinan H, Bartel K, Keller M, Robaa D, Teupser D, Holdt LM, Vollmar AM, Sippl W, Puertollano R, Medina D, Biel M, Wahl-Schott C, Bracher F, Grimm C. Plesch E, et al. Among authors: krogsaeter ek. Elife. 2018 Nov 27;7:e39720. doi: 10.7554/eLife.39720. Elife. 2018. PMID: 30479274 Free PMC article.
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function.
Gerndt S, Chen CC, Chao YK, Yuan Y, Burgstaller S, Scotto Rosato A, Krogsaeter E, Urban N, Jacob K, Nguyen ONP, Miller MT, Keller M, Vollmar AM, Gudermann T, Zierler S, Schredelseker J, Schaefer M, Biel M, Malli R, Wahl-Schott C, Bracher F, Patel S, Grimm C. Gerndt S, et al. Elife. 2020 Mar 16;9:e54712. doi: 10.7554/eLife.54712. Elife. 2020. PMID: 32167471 Free PMC article.
Discovery of lipophilic two-pore channel agonists.
Gerndt S, Krogsaeter E, Patel S, Bracher F, Grimm C. Gerndt S, et al. FEBS J. 2020 Dec;287(24):5284-5293. doi: 10.1111/febs.15432. Epub 2020 Jun 14. FEBS J. 2020. PMID: 32478984 Free article. Review.
Evolutionary Aspects of TRPMLs and TPCs.
Jaślan D, Böck J, Krogsaeter E, Grimm C. Jaślan D, et al. Int J Mol Sci. 2020 Jun 11;21(11):4181. doi: 10.3390/ijms21114181. Int J Mol Sci. 2020. PMID: 32545371 Free PMC article. Review.
15 results