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Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss.
Lucas S, Omata Y, Hofmann J, Böttcher M, Iljazovic A, Sarter K, Albrecht O, Schulz O, Krishnacoumar B, Krönke G, Herrmann M, Mougiakakos D, Strowig T, Schett G, Zaiss MM. Lucas S, et al. Among authors: krishnacoumar b. Nat Commun. 2018 Jan 4;9(1):55. doi: 10.1038/s41467-017-02490-4. Nat Commun. 2018. PMID: 29302038 Free PMC article.
PPARδ-mediated mitochondrial rewiring of osteoblasts determines bone mass.
Müller DIH, Stoll C, Palumbo-Zerr K, Böhm C, Krishnacoumar B, Ipseiz N, Taubmann J, Zimmermann M, Böttcher M, Mougiakakos D, Tuckermann J, Djouad F, Schett G, Scholtysek C, Krönke G. Müller DIH, et al. Among authors: krishnacoumar b. Sci Rep. 2020 May 21;10(1):8428. doi: 10.1038/s41598-020-65305-5. Sci Rep. 2020. PMID: 32439961 Free PMC article.
NR4A1 Regulates Motility of Osteoclast Precursors and Serves as Target for the Modulation of Systemic Bone Turnover.
Scholtysek C, Ipseiz N, Böhm C, Krishnacoumar B, Stenzel M, Czerwinski T, Palumbo-Zerr K, Rothe T, Weidner D, Klej A, Stoll C, Distler J, Tuckermann J, Herrmann M, Fabry B, Goldmann WH, Schett G, Krönke G. Scholtysek C, et al. Among authors: krishnacoumar b. J Bone Miner Res. 2018 Nov;33(11):2035-2047. doi: 10.1002/jbmr.3533. Epub 2018 Jul 24. J Bone Miner Res. 2018. PMID: 29949664 Free article.
Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids.
Auger JP, Zimmermann M, Faas M, Stifel U, Chambers D, Krishnacoumar B, Taudte RV, Grund C, Erdmann G, Scholtysek C, Uderhardt S, Ben Brahim O, Pascual Maté M, Stoll C, Böttcher M, Palumbo-Zerr K, Mangan MSJ, Dzamukova M, Kieler M, Hofmann M, Blüml S, Schabbauer G, Mougiakakos D, Sonnewald U, Hartmann F, Simon D, Kleyer A, Grüneboom A, Finotto S, Latz E, Hofmann J, Schett G, Tuckermann J, Krönke G. Auger JP, et al. Among authors: krishnacoumar b. Nature. 2024 May;629(8010):184-192. doi: 10.1038/s41586-024-07282-7. Epub 2024 Apr 10. Nature. 2024. PMID: 38600378