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Cardiac metabolism as a driver and therapeutic target of myocardial infarction.
Zuurbier CJ, Bertrand L, Beauloye CR, Andreadou I, Ruiz-Meana M, Jespersen NR, Kula-Alwar D, Prag HA, Eric Botker H, Dambrova M, Montessuit C, Kaambre T, Liepinsh E, Brookes PS, Krieg T. Zuurbier CJ, et al. Among authors: krieg t. J Cell Mol Med. 2020 Jun;24(11):5937-5954. doi: 10.1111/jcmm.15180. Epub 2020 May 8. J Cell Mol Med. 2020. PMID: 32384583 Free PMC article. Review.
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I.
Chouchani ET, Methner C, Nadtochiy SM, Logan A, Pell VR, Ding S, James AM, Cochemé HM, Reinhold J, Lilley KS, Partridge L, Fearnley IM, Robinson AJ, Hartley RC, Smith RA, Krieg T, Brookes PS, Murphy MP. Chouchani ET, et al. Among authors: krieg t. Nat Med. 2013 Jun;19(6):753-9. doi: 10.1038/nm.3212. Epub 2013 May 26. Nat Med. 2013. PMID: 23708290 Free PMC article.
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
Chouchani ET, Pell VR, Gaude E, Aksentijević D, Sundier SY, Robb EL, Logan A, Nadtochiy SM, Ord ENJ, Smith AC, Eyassu F, Shirley R, Hu CH, Dare AJ, James AM, Rogatti S, Hartley RC, Eaton S, Costa ASH, Brookes PS, Davidson SM, Duchen MR, Saeb-Parsy K, Shattock MJ, Robinson AJ, Work LM, Frezza C, Krieg T, Murphy MP. Chouchani ET, et al. Among authors: krieg t. Nature. 2014 Nov 20;515(7527):431-435. doi: 10.1038/nature13909. Epub 2014 Nov 5. Nature. 2014. PMID: 25383517 Free PMC article.
Targeting Succinate Metabolism in Ischemia/Reperfusion Injury.
Kula-Alwar D, Prag HA, Krieg T. Kula-Alwar D, et al. Among authors: krieg t. Circulation. 2019 Dec 10;140(24):1968-1970. doi: 10.1161/CIRCULATIONAHA.119.042791. Epub 2019 Dec 9. Circulation. 2019. PMID: 31815541 Review. No abstract available.
Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia.
Szibor M, Schreckenberg R, Gizatullina Z, Dufour E, Wiesnet M, Dhandapani PK, Debska-Vielhaber G, Heidler J, Wittig I, Nyman TA, Gärtner U, Hall AR, Pell V, Viscomi C, Krieg T, Murphy MP, Braun T, Gellerich FN, Schlüter KD, Jacobs HT. Szibor M, et al. Among authors: krieg t. J Cell Mol Med. 2020 Mar;24(6):3534-3548. doi: 10.1111/jcmm.15043. Epub 2020 Feb 10. J Cell Mol Med. 2020. PMID: 32040259 Free PMC article.
Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation.
Martin JL, Costa ASH, Gruszczyk AV, Beach TE, Allen FM, Prag HA, Hinchy EC, Mahbubani K, Hamed M, Tronci L, Nikitopoulou E, James AM, Krieg T, Robinson AJ, Huang MM, Caldwell ST, Logan A, Pala L, Hartley RC, Frezza C, Saeb-Parsy K, Murphy MP. Martin JL, et al. Among authors: krieg t. Nat Metab. 2019 Sep 30;1:966-974. doi: 10.1038/s42255-019-0115-y. Nat Metab. 2019. PMID: 32395697 Free PMC article.
Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo.
Prag HA, Pala L, Kula-Alwar D, Mulvey JF, Luping D, Beach TE, Booty LM, Hall AR, Logan A, Sauchanka V, Caldwell ST, Robb EL, James AM, Xu Z, Saeb-Parsy K, Hartley RC, Murphy MP, Krieg T. Prag HA, et al. Among authors: krieg t. Cardiovasc Drugs Ther. 2022 Feb;36(1):1-13. doi: 10.1007/s10557-020-07033-6. Epub 2020 Jul 9. Cardiovasc Drugs Ther. 2022. PMID: 32648168 Free PMC article.
663 results