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From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution.
Van Anh TT, Mostafa A, Rao Z, Pace S, Schwaiger S, Kretzer C, Temml V, Giesel C, Jordan PM, Bilancia R, Weinigel C, Rummler S, Waltenberger B, Hung T, Rossi A, Stuppner H, Werz O, Koeberle A. Van Anh TT, et al. Among authors: kretzer c. Acta Pharm Sin B. 2021 Jun;11(6):1629-1647. doi: 10.1016/j.apsb.2021.04.011. Epub 2021 Apr 20. Acta Pharm Sin B. 2021. PMID: 34221873 Free PMC article.
Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages.
Kretzer C, Jordan PM, Meyer KPL, Hoff D, Werner M, Hofstetter RK, Koeberle A, Cala Peralta A, Viault G, Seraphin D, Richomme P, Helesbeux JJ, Stuppner H, Temml V, Schuster D, Werz O. Kretzer C, et al. Biochem Pharmacol. 2022 Jan;195:114825. doi: 10.1016/j.bcp.2021.114825. Epub 2021 Nov 8. Biochem Pharmacol. 2022. PMID: 34762841
Rotational constriction of curcuminoids impacts 5-lipoxygenase and mPGES-1 inhibition and evokes a lipid mediator class switch in macrophages.
Rao Z, Caprioglio D, Gollowitzer A, Kretzer C, Imperio D, Collado JA, Waltl L, Lackner S, Appendino G, Muñoz E, Temml V, Werz O, Minassi A, Koeberle A. Rao Z, et al. Among authors: kretzer c. Biochem Pharmacol. 2022 Sep;203:115202. doi: 10.1016/j.bcp.2022.115202. Epub 2022 Aug 3. Biochem Pharmacol. 2022. PMID: 35932797 Free article.
Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome.
Werner M, Jordan PM, Romp E, Czapka A, Rao Z, Kretzer C, Koeberle A, Garscha U, Pace S, Claesson HE, Serhan CN, Werz O, Gerstmeier J. Werner M, et al. Among authors: kretzer c. FASEB J. 2019 May;33(5):6140-6153. doi: 10.1096/fj.201802509R. Epub 2019 Feb 8. FASEB J. 2019. PMID: 30735438 Free PMC article.
Our data may allow better appraisal of the therapeutic potential of these drugs to intervene with inflammatory disorders.-Werner, M., Jordan, P. M., Romp, E., Czapka, A., Rao, Z., Kretzer, C., Koeberle, A., Garscha, U., Pace, S., Claesson, H.-E., Serhan, C. . …
Our data may allow better appraisal of the therapeutic potential of these drugs to intervene with inflammatory disorders.-Werner, M., Jordan …
Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators.
Pace S, Zhang K, Jordan PM, Bilancia R, Wang W, Börner F, Hofstetter RK, Potenza M, Kretzer C, Gerstmeier J, Fischer D, Lorkowski S, Gilbert NC, Newcomer ME, Rossi A, Chen X, Werz O. Pace S, et al. Among authors: kretzer c. Pharmacol Res. 2021 May;167:105556. doi: 10.1016/j.phrs.2021.105556. Epub 2021 Mar 31. Pharmacol Res. 2021. PMID: 33812006
Novel benzoxanthene lignans that favorably modulate lipid mediator biosynthesis: A promising pharmacological strategy for anti-inflammatory therapy.
Gerstmeier J, Kretzer C, Di Micco S, Miek L, Butschek H, Cantone V, Bilancia R, Rizza R, Troisi F, Cardullo N, Tringali C, Ialenti A, Rossi A, Bifulco G, Werz O, Pace S. Gerstmeier J, et al. Among authors: kretzer c. Biochem Pharmacol. 2019 Jul;165:263-274. doi: 10.1016/j.bcp.2019.03.003. Epub 2019 Mar 2. Biochem Pharmacol. 2019. PMID: 30836057
Encapsulation of the dual FLAP/mPEGS-1 inhibitor BRP-187 into acetalated dextran and PLGA nanoparticles improves its cellular bioactivity.
Shkodra-Pula B, Kretzer C, Jordan PM, Klemm P, Koeberle A, Pretzel D, Banoglu E, Lorkowski S, Wallert M, Höppener S, Stumpf S, Vollrath A, Schubert S, Werz O, Schubert US. Shkodra-Pula B, et al. Among authors: kretzer c. J Nanobiotechnology. 2020 May 14;18(1):73. doi: 10.1186/s12951-020-00620-7. J Nanobiotechnology. 2020. PMID: 32408877 Free PMC article.
Ethoxy acetalated dextran-based nanocarriers accomplish efficient inhibition of leukotriene formation by a novel FLAP antagonist in human leukocytes and blood.
Kretzer C, Shkodra B, Klemm P, Jordan PM, Schröder D, Cinar G, Vollrath A, Schubert S, Nischang I, Hoeppener S, Stumpf S, Banoglu E, Gladigau F, Bilancia R, Rossi A, Eggeling C, Neugebauer U, Schubert US, Werz O. Kretzer C, et al. Cell Mol Life Sci. 2021 Dec 31;79(1):40. doi: 10.1007/s00018-021-04039-7. Cell Mol Life Sci. 2021. PMID: 34971430 Free PMC article.
22 results