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The complexity of lipoprotein (a) lowering by PCSK9 monoclonal antibodies.
Lambert G, Thedrez A, Croyal M, Ramin-Mangata S, Couret D, Diotel N, Nobécourt-Dupuy E, Krempf M, LeBail JC, Poirier B, Blankenstein J, Villard EF, Guillot E. Lambert G, et al. Among authors: krempf m. Clin Sci (Lond). 2017 Feb 1;131(4):261-268. doi: 10.1042/CS20160403. Clin Sci (Lond). 2017. PMID: 28108631 Review.
PCSK9 Modulates the Secretion But Not the Cellular Uptake of Lipoprotein(a) Ex Vivo: An Effect Blunted by Alirocumab.
Villard EF, Thedrez A, Blankenstein J, Croyal M, Tran TT, Poirier B, Le Bail JC, Illiano S, Nobécourt E, Krempf M, Blom DJ, Marais AD, Janiak P, Muslin AJ, Guillot E, Lambert G. Villard EF, et al. Among authors: krempf m. JACC Basic Transl Sci. 2016 Oct;1(6):419-427. doi: 10.1016/j.jacbts.2016.06.006. JACC Basic Transl Sci. 2016. PMID: 29308438 Free PMC article.
PCSK9 inhibition with alirocumab reduces lipoprotein(a) levels in nonhuman primates by lowering apolipoprotein(a) production rate.
Croyal M, Tran TT, Blanchard RH, Le Bail JC, Villard EF, Poirier B, Aguesse A, Billon-Crossouard S, Ramin-Mangata S, Blanchard V, Nativel B, Chemello K, Khantalin I, Thedrez A, Janiak P, Krempf M, Boixel C, Lambert G, Guillot E. Croyal M, et al. Among authors: krempf m. Clin Sci (Lond). 2018 May 31;132(10):1075-1083. doi: 10.1042/CS20180040. Print 2018 May 31. Clin Sci (Lond). 2018. PMID: 29724769
PCSK9: a promising therapeutic target for dyslipidemias?
Lambert G, Krempf M, Costet P. Lambert G, et al. Among authors: krempf m. Trends Endocrinol Metab. 2006 Apr;17(3):79-81. doi: 10.1016/j.tem.2006.02.001. Epub 2006 Feb 17. Trends Endocrinol Metab. 2006. PMID: 16487721
Plasma PCSK9 measurement by liquid chromatography-Tandem mass spectrometry and comparison with conventional ELISA.
Croyal M, Fall F, Krempf M, Thédrez A, Ouguerram K, Ferchaud-Roucher V, Aguesse A, Billon-Crossouard S, Mata P, Alonso R, Lambert G, Nobécourt E. Croyal M, et al. Among authors: krempf m. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Feb 15;1044-1045:24-29. doi: 10.1016/j.jchromb.2016.12.040. Epub 2016 Dec 31. J Chromatogr B Analyt Technol Biomed Life Sci. 2017. PMID: 28064066
VLDL (Very-Low-Density Lipoprotein)-Apo E (Apolipoprotein E) May Influence Lp(a) (Lipoprotein [a]) Synthesis or Assembly.
Croyal M, Blanchard V, Ouguerram K, Chétiveaux M, Cabioch L, Moyon T, Billon-Crossouard S, Aguesse A, Bernardeau K, Le May C, Flet L, Lambert G, Hadjadj S, Cariou B, Krempf M, Nobécourt-Dupuy E. Croyal M, et al. Among authors: krempf m. Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):819-829. doi: 10.1161/ATVBAHA.119.313877. Epub 2020 Feb 6. Arterioscler Thromb Vasc Biol. 2020. PMID: 32078365 Free article.
Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor.
Lambert G, Jarnoux AL, Pineau T, Pape O, Chetiveaux M, Laboisse C, Krempf M, Costet P. Lambert G, et al. Among authors: krempf m. Endocrinology. 2006 Oct;147(10):4985-95. doi: 10.1210/en.2006-0098. Epub 2006 Jun 22. Endocrinology. 2006. PMID: 16794006
Effects of Extended-Release Nicotinic Acid on Apolipoprotein (a) Kinetics in Hypertriglyceridemic Patients.
Croyal M, Ouguerram K, Passard M, Ferchaud-Roucher V, Chétiveaux M, Billon-Crossouard S, de Gouville AC, Lambert G, Krempf M, Nobécourt E. Croyal M, et al. Among authors: krempf m. Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):2042-7. doi: 10.1161/ATVBAHA.115.305835. Epub 2015 Jul 9. Arterioscler Thromb Vasc Biol. 2015. PMID: 26160958 Clinical Trial.
310 results