Krekels EHJ - Search Results

1

Mechanistic and Quantitative Understanding of Pharmacokinetics in Zebrafish Larvae through Nanoscale Blood Sampling and Metabolite Modeling of Paracetamol.

Van Wijk RC, Krekels EHJ, Kantae V, Ordas A, Kreling T, Harms AC, Hankemeier T, Spaink HP, van der Graaf PH. Van Wijk RC, et al. Among authors: krekels ehj. J Pharmacol Exp Ther. 2019 Oct;371(1):15-24. doi: 10.1124/jpet.119.260299. Epub 2019 Aug 1. J Pharmacol Exp Ther. 2019. PMID: 31371482

2

Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants.

Krekels EH, van Ham S, Allegaert K, de Hoon J, Tibboel D, Danhof M, Knibbe CA. Krekels EH, et al. Eur J Clin Pharmacol. 2015 Sep;71(9):1075-82. doi: 10.1007/s00228-015-1887-y. Epub 2015 Jul 3. Eur J Clin Pharmacol. 2015. PMID: 26139379 Free PMC article. Clinical Trial.

3

Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude.

Kantae V, Krekels EH, Ordas A, González O, van Wijk RC, Harms AC, Racz PI, van der Graaf PH, Spaink HP, Hankemeier T. Kantae V, et al. Zebrafish. 2016 Dec;13(6):504-510. doi: 10.1089/zeb.2016.1313. Epub 2016 Sep 15. Zebrafish. 2016. PMID: 27632065 Free PMC article.

4

Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy.

Kantae V, Krekels EHJ, Esdonk MJV, Lindenburg P, Harms AC, Knibbe CAJ, Van der Graaf PH, Hankemeier T. Kantae V, et al. Among authors: krekels ehj. Metabolomics. 2017;13(1):9. doi: 10.1007/s11306-016-1143-1. Epub 2016 Dec 19. Metabolomics. 2017. PMID: 28058041 Free PMC article.

5

Towards personalized treatment of pain using a quantitative systems pharmacology approach.

Goulooze SC, Krekels EHJ, van Dijk M, Tibboel D, van der Graaf PH, Hankemeier T, Knibbe CAJ, van Hasselt JGC. Goulooze SC, et al. Among authors: krekels ehj. Eur J Pharm Sci. 2017 Nov 15;109S:S32-S38. doi: 10.1016/j.ejps.2017.05.027. Epub 2017 May 12. Eur J Pharm Sci. 2017. PMID: 28506867 Free article. Review.

6

Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments.

Calvier EAM, Krekels EHJ, Yu H, Välitalo PAJ, Johnson TN, Rostami-Hodjegan A, Tibboel D, van der Graaf PH, Danhof M, Knibbe CAJ. Calvier EAM, et al. Among authors: krekels ehj. CPT Pharmacometrics Syst Pharmacol. 2018 Mar;7(3):175-185. doi: 10.1002/psp4.12273. Epub 2018 Feb 5. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 29399979 Free PMC article.

7

Outside-In Systems Pharmacology Combines Innovative Computational Methods With High-Throughput Whole Vertebrate Studies.

Schulthess P, van Wijk RC, Krekels EHJ, Yates JWT, Spaink HP, van der Graaf PH. Schulthess P, et al. Among authors: krekels ehj. CPT Pharmacometrics Syst Pharmacol. 2018 May;7(5):285-287. doi: 10.1002/psp4.12297. Epub 2018 Apr 25. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 29693322 Free PMC article.

8

Covariates in Pharmacometric Repeated Time-to-Event Models: Old and New (Pre)Selection Tools.

Goulooze SC, Krekels EHJ, Hankemeier T, Knibbe CAJ. Goulooze SC, et al. Among authors: krekels ehj. AAPS J. 2018 Dec 18;21(1):11. doi: 10.1208/s12248-018-0278-6. AAPS J. 2018. PMID: 30565031

9

Population Pharmacokinetic Modeling of Acetaminophen and Metabolites in Children After Cardiac Surgery With Cardiopulmonary Bypass.

Mian P, Valkenburg AJ, Allegaert K, Koch BCP, Breatnach CV, Knibbe CAJ, Tibboel D, Krekels EHJ. Mian P, et al. Among authors: krekels ehj. J Clin Pharmacol. 2019 Jun;59(6):847-855. doi: 10.1002/jcph.1373. Epub 2019 Jan 11. J Clin Pharmacol. 2019. PMID: 30633373 Free PMC article.

10

Children Are Not Small Adults, but Can We Treat Them As Such?

Krekels EHJ, Calvier EAM, van der Graaf PH, Knibbe CAJ. Krekels EHJ, et al. CPT Pharmacometrics Syst Pharmacol. 2019 Jan;8(1):34-38. doi: 10.1002/psp4.12366. Epub 2019 Jan 28. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 30689298 Free PMC article.

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