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Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making.
Paini A, Leonard JA, Joossens E, Bessems JGM, Desalegn A, Dorne JL, Gosling JP, Heringa MB, Klaric M, Kliment T, Kramer NI, Loizou G, Louisse J, Lumen A, Madden JC, Patterson EA, Proença S, Punt A, Setzer RW, Suciu N, Troutman J, Yoon M, Worth A, Tan YM. Paini A, et al. Among authors: kramer ni. Comput Toxicol. 2019 Feb;9:61-72. doi: 10.1016/j.comtox.2018.11.002. Comput Toxicol. 2019. PMID: 31008414 Free PMC article. Review.
Application of the Adverse Outcome Pathway Concept to In Vitro Nephrotoxicity Assessment: Kidney Injury due to Receptor-Mediated Endocytosis and Lysosomal Overload as a Case Study.
Jarzina S, Di Fiore S, Ellinger B, Reiser P, Frank S, Glaser M, Wu J, Taverne FJ, Kramer NI, Mally A. Jarzina S, et al. Among authors: kramer ni. Front Toxicol. 2022 Apr 19;4:864441. doi: 10.3389/ftox.2022.864441. eCollection 2022. Front Toxicol. 2022. PMID: 35516525 Free PMC article.
Acetylcholinesterase Inhibition in Rats and Humans Following Acute Fenitrothion Exposure Predicted by Physiologically Based Kinetic Modeling-Facilitated Quantitative In Vitro to In Vivo Extrapolation.
Chen J, Zhao S, Wesseling S, Kramer NI, Rietjens IMCM, Bouwmeester H. Chen J, et al. Among authors: kramer ni. Environ Sci Technol. 2023 Dec 12;57(49):20521-20531. doi: 10.1021/acs.est.3c07077. Epub 2023 Nov 26. Environ Sci Technol. 2023. PMID: 38008925 Free PMC article.
52 results