Kramer NI - Search Results

1

Drug Metabolism of Hepatocyte-like Organoids and Their Applicability in In Vitro Toxicity Testing.

Bouwmeester MC, Tao Y, Proença S, van Steenbeek FG, Samsom RA, Nijmeijer SM, Sinnige T, van der Laan LJW, Legler J, Schneeberger K, Kramer NI, Spee B. Bouwmeester MC, et al. Among authors: kramer ni. Molecules. 2023 Jan 7;28(2):621. doi: 10.3390/molecules28020621. Molecules. 2023. PMID: 36677681 Free PMC article.

2

New approach methodologies (NAMs) for human-relevant biokinetics predictions. Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment.

Punt A, Bouwmeester H, Blaauboer BJ, Coecke S, Hakkert B, Hendriks DFG, Jennings P, Kramer NI, Neuhoff S, Masereeuw R, Paini A, Peijnenburg AACM, Rooseboom M, Shuler ML, Sorrell I, Spee B, Strikwold M, Van der Meer AD, Van der Zande M, Vinken M, Yang H, Bos PMJ, Heringa MB. Punt A, et al. Among authors: kramer ni. ALTEX. 2020;37(4):607-622. doi: 10.14573/altex.2003242. Epub 2020 Jun 8. ALTEX. 2020. PMID: 32521035 Free article.

3

Acetylcholinesterase inhibition in electric eel and human donor blood: an in vitro approach to investigate interspecies differences and human variability in toxicodynamics.

Kasteel EEJ, Nijmeijer SM, Darney K, Lautz LS, Dorne JLCM, Kramer NI, Westerink RHS. Kasteel EEJ, et al. Among authors: kramer ni. Arch Toxicol. 2020 Dec;94(12):4055-4065. doi: 10.1007/s00204-020-02927-8. Epub 2020 Oct 10. Arch Toxicol. 2020. PMID: 33037899 Free PMC article.

4

QSAR Models for Human Carcinogenicity: An Assessment Based on Oral and Inhalation Slope Factors.

Toma C, Manganaro A, Raitano G, Marzo M, Gadaleta D, Baderna D, Roncaglioni A, Kramer N, Benfenati E. Toma C, et al. Molecules. 2020 Dec 29;26(1):127. doi: 10.3390/molecules26010127. Molecules. 2020. PMID: 33383938 Free PMC article.

5

Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models.

Proença S, Escher BI, Fischer FC, Fisher C, Grégoire S, Hewitt NJ, Nicol B, Paini A, Kramer NI. Proença S, et al. Among authors: kramer ni. Toxicol In Vitro. 2021 Jun;73:105133. doi: 10.1016/j.tiv.2021.105133. Epub 2021 Mar 1. Toxicol In Vitro. 2021. PMID: 33662518 Free article. Review.

6

Bioprinting of Human Liver-Derived Epithelial Organoids for Toxicity Studies.

Bouwmeester MC, Bernal PN, Oosterhoff LA, van Wolferen ME, Lehmann V, Vermaas M, Buchholz MB, Peiffer QC, Malda J, van der Laan LJW, Kramer NI, Schneeberger K, Levato R, Spee B. Bouwmeester MC, et al. Among authors: kramer ni. Macromol Biosci. 2021 Dec;21(12):e2100327. doi: 10.1002/mabi.202100327. Epub 2021 Oct 5. Macromol Biosci. 2021. PMID: 34559943

7

HiPSC-Derived Hepatocyte-like Cells Can Be Used as a Model for Transcriptomics-Based Study of Chemical Toxicity.

Ghosh S, De Smedt J, Tricot T, Proença S, Kumar M, Nami F, Vanwelden T, Vidal N, Jennings P, Kramer NI, Verfaillie CM. Ghosh S, et al. Among authors: kramer ni. Toxics. 2021 Dec 21;10(1):1. doi: 10.3390/toxics10010001. Toxics. 2021. PMID: 35051043 Free PMC article.

8

The effects of hexabromocyclododecane on the transcriptome and hepatic enzyme activity in three human HepaRG-based models.

Proença S, van Sabben N, Legler J, Kamstra JH, Kramer NI. Proença S, et al. Among authors: kramer ni. Toxicology. 2023 Feb;485:153411. doi: 10.1016/j.tox.2022.153411. Epub 2022 Dec 23. Toxicology. 2023. PMID: 36572169 Free article.

9

Integrating distribution kinetics and toxicodynamics to assess repeat dose neurotoxicity in vitro using human BrainSpheres: a case study on amiodarone.

Nunes C, Proença S, Ambrosini G, Pamies D, Thomas A, Kramer NI, Zurich MG. Nunes C, et al. Among authors: kramer ni. Front Pharmacol. 2023 Sep 6;14:1248882. doi: 10.3389/fphar.2023.1248882. eCollection 2023. Front Pharmacol. 2023. PMID: 37745076 Free PMC article.

10

The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans.

Blaauboer BJ, Boekelheide K, Clewell HJ, Daneshian M, Dingemans MM, Goldberg AM, Heneweer M, Jaworska J, Kramer NI, Leist M, Seibert H, Testai E, Vandebriel RJ, Yager JD, Zurlo J. Blaauboer BJ, et al. Among authors: kramer ni. ALTEX. 2012;29(4):411-25. doi: 10.14573/altex.2012.4.411. ALTEX. 2012. PMID: 23138511

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