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Specific inhibition of Wee1 kinase and Rad51 recombinase: a strategy to enhance the sensitivity of leukemic T-cells to ionizing radiation-induced DNA double-strand breaks.
Havelek R, Cmielova J, Kralovec K, Bruckova L, Bilkova Z, Fousova I, Sinkorova Z, Vavrova J, Rezacova M. Havelek R, et al. Among authors: kralovec k. Biochem Biophys Res Commun. 2014 Oct 24;453(3):569-75. doi: 10.1016/j.bbrc.2014.09.123. Epub 2014 Oct 5. Biochem Biophys Res Commun. 2014. PMID: 25285634
Synthesis, structural characterization, docking, lipophilicity and cytotoxicity of 1-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-3-alkyl carbamates, novel acetylcholinesterase and butyrylcholinesterase pseudo-irreversible inhibitors.
Pejchal V, Štěpánková Š, Pejchalová M, Královec K, Havelek R, Růžičková Z, Ajani H, Lo R, Lepšík M. Pejchal V, et al. Among authors: kralovec k. Bioorg Med Chem. 2016 Apr 1;24(7):1560-72. doi: 10.1016/j.bmc.2016.02.033. Epub 2016 Feb 26. Bioorg Med Chem. 2016. PMID: 26947959
Comparative cytotoxicity of chelidonine and homochelidonine, the dimethoxy analogues isolated from Chelidonium majus L. (Papaveraceae), against human leukemic and lung carcinoma cells.
Havelek R, Seifrtova M, Kralovec K, Krocova E, Tejkalova V, Novotny I, Cahlikova L, Safratova M, Opletal L, Bilkova Z, Vavrova J, Rezacova M. Havelek R, et al. Among authors: kralovec k. Phytomedicine. 2016 Mar 15;23(3):253-66. doi: 10.1016/j.phymed.2016.01.001. Epub 2016 Jan 22. Phytomedicine. 2016. PMID: 26969379
Anticancer potential of Amaryllidaceae alkaloids evaluated by screening with a panel of human cells, real-time cellular analysis and Ehrlich tumor-bearing mice.
Havelek R, Muthna D, Tomsik P, Kralovec K, Seifrtova M, Cahlikova L, Hostalkova A, Safratova M, Perwein M, Cermakova E, Rezacova M. Havelek R, et al. Among authors: kralovec k. Chem Biol Interact. 2017 Sep 25;275:121-132. doi: 10.1016/j.cbi.2017.07.018. Epub 2017 Jul 26. Chem Biol Interact. 2017. PMID: 28756149
Silica coated iron oxide nanoparticles-induced cytotoxicity, genotoxicity and its underlying mechanism in human HK-2 renal proximal tubule epithelial cells.
Královec K, Havelek R, Kročová E, Kučírková L, Hauschke M, Bartáček J, Palarčík J, Sedlák M. Královec K, et al. Mutat Res Genet Toxicol Environ Mutagen. 2019 Aug;844:35-45. doi: 10.1016/j.mrgentox.2019.05.015. Epub 2019 May 30. Mutat Res Genet Toxicol Environ Mutagen. 2019. PMID: 31326033
39 results