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Specificity, synergy, and mechanisms of splice-modifying drugs.
Ishigami Y, Wong MS, Martí-Gómez C, Ayaz A, Kooshkbaghi M, Hanson SM, McCandlish DM, Krainer AR, Kinney JB. Ishigami Y, et al. Among authors: krainer ar. Nat Commun. 2024 Feb 29;15(1):1880. doi: 10.1038/s41467-024-46090-5. Nat Commun. 2024. PMID: 38424098 Free PMC article.
Opportunities and challenges for innovative and equitable healthcare.
Ecker DJ, Aiello CD, Arron JR, Bennett CF, Bernard A, Breakefield XO, Broderick TJ, Callier SL, Canton B, Chen JS, Fishburn CS, Garrett B, Hecht SM, Janowitz T, Kliegman M, Krainer A, Louis CU, Lowe C, Sehgal A, Tozan Y, Tracey KJ, Urnov F, Wattendorf D, Williams TW, Zhao X, Hayden MR. Ecker DJ, et al. Among authors: krainer a. Nat Rev Drug Discov. 2024 Feb 26. doi: 10.1038/d41573-024-00032-4. Online ahead of print. Nat Rev Drug Discov. 2024. PMID: 38409339 No abstract available.
Mechanistically based blood proteomic markers in the TGF-β pathway stratify risk of hepatocellular cancer in patients with cirrhosis.
Xiang X, Bhowmick K, Shetty K, Ohshiro K, Yang X, Wong LL, Yu H, Latham PS, Satapathy SK, Brennan C, Dima RJ, Chambwe N, Sharifova G, Cacaj F, John S, Crawford JM, Huang H, Dasarathy S, Krainer AR, He AR, Amdur RL, Mishra L. Xiang X, et al. Among authors: krainer ar. Genes Cancer. 2024 Feb 1;15:1-14. doi: 10.18632/genesandcancer.234. eCollection 2024. Genes Cancer. 2024. PMID: 38323119 Free PMC article.
Antisense oligonucleotide therapy for H3.3K27M diffuse midline glioma.
Zhang Q, Yang L, Liu YH, Wilkinson JE, Krainer AR. Zhang Q, et al. Among authors: krainer ar. Sci Transl Med. 2023 Apr 12;15(691):eadd8280. doi: 10.1126/scitranslmed.add8280. Epub 2023 Apr 12. Sci Transl Med. 2023. PMID: 37043556 Free PMC article.
RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer.
Jbara A, Lin KT, Stossel C, Siegfried Z, Shqerat H, Amar-Schwartz A, Elyada E, Mogilevsky M, Raitses-Gurevich M, Johnson JL, Yaron TM, Ovadia O, Jang GH, Danan-Gotthold M, Cantley LC, Levanon EY, Gallinger S, Krainer AR, Golan T, Karni R. Jbara A, et al. Among authors: krainer ar. Nature. 2023 May;617(7959):147-153. doi: 10.1038/s41586-023-05820-3. Epub 2023 Mar 22. Nature. 2023. PMID: 36949200 Free PMC article.
RNA therapeutics.
Hastings ML, Krainer AR. Hastings ML, et al. Among authors: krainer ar. RNA. 2023 Apr;29(4):393-395. doi: 10.1261/rna.079626.123. RNA. 2023. PMID: 36928165 Free PMC article.
230 results