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Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma.
Headland SE, Dengler HS, Xu D, Teng G, Everett C, Ratsimandresy RA, Yan D, Kang J, Ganeshan K, Nazarova EV, Gierke S, Wedeles CJ, Guidi R, DePianto DJ, Morshead KB, Huynh A, Mills J, Flanagan S, Hambro S, Nunez V, Klementowicz JE, Shi Y, Wang J, Bevers J 3rd, Ramirez-Carrozzi V, Pappu R, Abbas A, Vander Heiden J, Choy DF, Yadav R, Modrusan Z, Panettieri RA Jr, Koziol-White C, Jester WF Jr, Jenkins BJ, Cao Y, Clarke C, Austin C, Lafkas D, Xu M, Wolters PJ, Arron JR, West NR, Wilson MS. Headland SE, et al. Sci Transl Med. 2022 Jan 12;14(627):eabf8188. doi: 10.1126/scitranslmed.abf8188. Epub 2022 Jan 12. Sci Transl Med. 2022. PMID: 35020406
Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma.
Ghosh A, Koziol-White CJ, Asosingh K, Cheng G, Ruple L, Groneberg D, Friebe A, Comhair SA, Stasch JP, Panettieri RA Jr, Aronica MA, Erzurum SC, Stuehr DJ. Ghosh A, et al. Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):E2355-62. doi: 10.1073/pnas.1524398113. Epub 2016 Apr 11. Proc Natl Acad Sci U S A. 2016. PMID: 27071111 Free PMC article.
RGS4 Overexpression in Lung Attenuates Airway Hyperresponsiveness in Mice.
Madigan LA, Wong GS, Gordon EM, Chen WS, Balenga N, Koziol-White CJ, Panettieri RA Jr, Levine SJ, Druey KM. Madigan LA, et al. Am J Respir Cell Mol Biol. 2018 Jan;58(1):89-98. doi: 10.1165/rcmb.2017-0109OC. Am J Respir Cell Mol Biol. 2018. PMID: 28853915 Free PMC article.
Gα12 facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3-kinase-mediated activation in a RhoA-dependent manner.
Yoo EJ, Cao G, Koziol-White CJ, Ojiaku CA, Sunder K, Jude JA, Michael JV, Lam H, Pushkarsky I, Damoiseaux R, Di Carlo D, Ahn K, An SS, Penn RB, Panettieri RA Jr. Yoo EJ, et al. Br J Pharmacol. 2017 Dec;174(23):4383-4395. doi: 10.1111/bph.14040. Epub 2017 Nov 12. Br J Pharmacol. 2017. PMID: 28921504 Free PMC article.
64 results