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Identification of critical residues in G(alpha)13 for stimulation of p115RhoGEF activity and the structure of the G(alpha)13-p115RhoGEF regulator of G protein signaling homology (RH) domain complex.
Hajicek N, Kukimoto-Niino M, Mishima-Tsumagari C, Chow CR, Shirouzu M, Terada T, Patel M, Yokoyama S, Kozasa T. Hajicek N, et al. Among authors: kozasa t. J Biol Chem. 2011 Jun 10;286(23):20625-36. doi: 10.1074/jbc.M110.201392. Epub 2011 Apr 20. J Biol Chem. 2011. PMID: 21507947 Free PMC article.
Modification of p115RhoGEF Ser(330) regulates its RhoGEF activity.
Chow CR, Suzuki N, Kawamura T, Hamakubo T, Kozasa T. Chow CR, et al. Among authors: kozasa t. Cell Signal. 2013 Nov;25(11):2085-92. doi: 10.1016/j.cellsig.2013.06.012. Epub 2013 Jun 29. Cell Signal. 2013. PMID: 23816534 Free PMC article.
Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF.
Suzuki N, Nakamura S, Mano H, Kozasa T. Suzuki N, et al. Among authors: kozasa t. Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):733-8. doi: 10.1073/pnas.0234057100. Epub 2003 Jan 6. Proc Natl Acad Sci U S A. 2003. PMID: 12515866 Free PMC article.
Recently, we identified p115RhoGEF, one of the guanine nucleotide exchange factors (GEFs) for Rho, as a direct link between Galpha13 and Rho [Kozasa, T., et al. (1998) Science 280, 2109-2111; Hart, M. J., et al. (1998) Science 280, 2112-2114]. ...
Recently, we identified p115RhoGEF, one of the guanine nucleotide exchange factors (GEFs) for Rho, as a direct link between Galpha13 and Rho …
132 results