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Host immunity contributes to the anti-melanoma activity of BRAF inhibitors.
Knight DA, Ngiow SF, Li M, Parmenter T, Mok S, Cass A, Haynes NM, Kinross K, Yagita H, Koya RC, Graeber TG, Ribas A, McArthur GA, Smyth MJ. Knight DA, et al. Among authors: koya rc. J Clin Invest. 2023 Dec 15;133(24):e177489. doi: 10.1172/JCI177489. J Clin Invest. 2023. PMID: 38099495 Free PMC article. No abstract available.
Implementation of a gene therapy education initiative by the ASGCT and Muhimbili University of Health and Allied Sciences.
Cornetta K, Kay S, Urio F, Minja IK, Mbugi E, Mgaya J, Mselle T, Nkya S, Alimohamed MZ, Ndaki K, Bonamino M, Koya RC, Shah LD, Mahlangu J, Drago D, Rangarajan S, Jayandharan GR. Cornetta K, et al. Among authors: koya rc. Mol Ther. 2023 Sep 6;31(9):2561-2565. doi: 10.1016/j.ymthe.2023.07.019. Epub 2023 Aug 17. Mol Ther. 2023. PMID: 37595584
Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses.
Mandula JK, Chang S, Mohamed E, Jimenez R, Sierra-Mondragon RA, Chang DC, Obermayer AN, Moran-Segura CM, Das S, Vazquez-Martinez JA, Prieto K, Chen A, Smalley KSM, Czerniecki B, Forsyth P, Koya RC, Ruffell B, Cubillos-Ruiz JR, Munn DH, Shaw TI, Conejo-Garcia JR, Rodriguez PC. Mandula JK, et al. Among authors: koya rc. Cancer Cell. 2022 Oct 10;40(10):1145-1160.e9. doi: 10.1016/j.ccell.2022.08.016. Epub 2022 Sep 22. Cancer Cell. 2022. PMID: 36150390 Free PMC article.
Tcf-1 protects anti-tumor TCR-engineered CD8+ T-cells from GzmB mediated self-destruction.
Zangari B, Tsuji T, Matsuzaki J, Mohammadpour H, Eppolito C, Battaglia S, Ito F, Chodon T, Koya R, Robert McGray AJ, Odunsi K. Zangari B, et al. Among authors: koya r. Cancer Immunol Immunother. 2022 Dec;71(12):2881-2898. doi: 10.1007/s00262-022-03197-2. Epub 2022 Apr 23. Cancer Immunol Immunother. 2022. PMID: 35460379 Free PMC article.
Metabolic adaptation of ovarian tumors in patients treated with an IDO1 inhibitor constrains antitumor immune responses.
Odunsi K, Qian F, Lugade AA, Yu H, Geller MA, Fling SP, Kaiser JC, Lacroix AM, D'Amico L, Ramchurren N, Morishima C, Disis ML, Dennis L, Danaher P, Warren S, Nguyen VA, Ravi S, Tsuji T, Rosario S, Zha W, Hutson A, Liu S, Lele S, Zsiros E, McGray AJR, Chiello J, Koya R, Chodon T, Morrison CD, Putluri V, Putluri N, Mager DE, Gunawan R, Cheever MA, Battaglia S, Matsuzaki J. Odunsi K, et al. Among authors: koya r. Sci Transl Med. 2022 Mar 16;14(636):eabg8402. doi: 10.1126/scitranslmed.abg8402. Epub 2022 Mar 16. Sci Transl Med. 2022. PMID: 35294258 Free PMC article.
Engineering tumor stromal mechanics for improved T cell therapy.
Ying L, Yazdani M, Koya R, Zhao R. Ying L, et al. Among authors: koya r. Biochim Biophys Acta Gen Subj. 2022 Apr;1866(4):130095. doi: 10.1016/j.bbagen.2022.130095. Epub 2022 Jan 22. Biochim Biophys Acta Gen Subj. 2022. PMID: 35077823 Review.
CXCR6 by increasing retention of memory CD8+ T cells in the ovarian tumor microenvironment promotes immunosurveillance and control of ovarian cancer.
Muthuswamy R, McGray AR, Battaglia S, He W, Miliotto A, Eppolito C, Matsuzaki J, Takemasa T, Koya R, Chodon T, Lichty BD, Shrikant P, Odunsi K. Muthuswamy R, et al. Among authors: koya r. J Immunother Cancer. 2021 Oct;9(10):e003329. doi: 10.1136/jitc-2021-003329. J Immunother Cancer. 2021. PMID: 34607898 Free PMC article.
94 results