Novel compounds that specifically bind and modulate MscL: insights into channel gating mechanisms.
Wray R, Iscla I, Kovacs Z, Wang J, Blount P.
Wray R, et al. Among authors: kovacs z.
FASEB J. 2019 Mar;33(3):3180-3189. doi: 10.1096/fj.201801628R. Epub 2018 Oct 25.
FASEB J. 2019.
PMID: 30359098
Free PMC article.
The data not only demonstrate that MscL is a viable antibiotic target, but also give insight into the gating mechanisms of MscL, and they may have implications for developing agonists for other channels.-Wray, R., Iscla, I., Kovacs, Z., Wang, J., Blount, P. Novel co …
The data not only demonstrate that MscL is a viable antibiotic target, but also give insight into the gating mechanisms of MscL, and they ma …