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ACAT as a drug target for Alzheimer's disease.
Huttunen HJ, Kovacs DM. Huttunen HJ, et al. Among authors: kovacs dm. Neurodegener Dis. 2008;5(3-4):212-4. doi: 10.1159/000113705. Epub 2008 Mar 6. Neurodegener Dis. 2008. PMID: 18322393 Free PMC article. Review.
Knockdown of ACAT-1 reduces amyloidogenic processing of APP.
Huttunen HJ, Greco C, Kovacs DM. Huttunen HJ, et al. Among authors: kovacs dm. FEBS Lett. 2007 Apr 17;581(8):1688-92. doi: 10.1016/j.febslet.2007.03.056. Epub 2007 Mar 30. FEBS Lett. 2007. PMID: 17412327 Free PMC article.
The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice.
Huttunen HJ, Havas D, Peach C, Barren C, Duller S, Xia W, Frosch MP, Hutter-Paier B, Windisch M, Kovacs DM. Huttunen HJ, et al. Among authors: kovacs dm. J Neuropathol Exp Neurol. 2010 Aug;69(8):777-88. doi: 10.1097/NEN.0b013e3181e77ed9. J Neuropathol Exp Neurol. 2010. PMID: 20613640 Free PMC article.
ACAT inhibition and amyloid beta reduction.
Bhattacharyya R, Kovacs DM. Bhattacharyya R, et al. Among authors: kovacs dm. Biochim Biophys Acta. 2010 Aug;1801(8):960-5. doi: 10.1016/j.bbalip.2010.04.003. Epub 2010 Apr 14. Biochim Biophys Acta. 2010. PMID: 20398792 Free PMC article. Review.
Alzheimer's disease: the cholesterol connection.
Puglielli L, Tanzi RE, Kovacs DM. Puglielli L, et al. Among authors: kovacs dm. Nat Neurosci. 2003 Apr;6(4):345-51. doi: 10.1038/nn0403-345. Nat Neurosci. 2003. PMID: 12658281 Review.
63 results