Kovach JS - Search Results

1

Inhibition of PP2A with LB-100 Enhances Efficacy of CAR-T Cell Therapy Against Glioblastoma.

Cui J, Wang H, Medina R, Zhang Q, Xu C, Indig IH, Zhou J, Song Q, Dmitriev P, Sun MY, Guo L, Wang Y, Rosenblum JS, Kovach JS, Gilbert MR, Zhuang Z. Cui J, et al. Among authors: kovach js. Cancers (Basel). 2020 Jan 6;12(1):139. doi: 10.3390/cancers12010139. Cancers (Basel). 2020. PMID: 31935881 Free PMC article.

2

Pharmacologic inhibition of protein phosphatase-2A achieves durable immune-mediated antitumor activity when combined with PD-1 blockade.

Ho WS, Wang H, Maggio D, Kovach JS, Zhang Q, Song Q, Marincola FM, Heiss JD, Gilbert MR, Lu R, Zhuang Z. Ho WS, et al. Among authors: kovach js. Nat Commun. 2018 May 29;9(1):2126. doi: 10.1038/s41467-018-04425-z. Nat Commun. 2018. PMID: 29844427 Free PMC article.

3

Inhibition of protein phosphatase-2A with LB-100 enhances antitumor immunity against glioblastoma.

Maggio D, Ho WS, Breese R, Walbridge S, Wang H, Cui J, Heiss JD, Gilbert MR, Kovach JS, Lu RO, Zhuang Z. Maggio D, et al. Among authors: kovach js. J Neurooncol. 2020 Jun;148(2):231-244. doi: 10.1007/s11060-020-03517-5. Epub 2020 Apr 27. J Neurooncol. 2020. PMID: 32342332 Free PMC article.

4

Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms.

Lu J, Kovach JS, Johnson F, Chiang J, Hodes R, Lonser R, Zhuang Z. Lu J, et al. Among authors: kovach js. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11697-702. doi: 10.1073/pnas.0905930106. Epub 2009 Jun 29. Proc Natl Acad Sci U S A. 2009. PMID: 19564615 Free PMC article.

5

Enhancement of cancer chemotherapy by simultaneously altering cell cycle progression and DNA-damage defenses through global modification of the serine/threonine phospho-proteome.

Zhuang Z, Lu J, Lonser R, Kovach JS. Zhuang Z, et al. Among authors: kovach js. Cell Cycle. 2009 Oct 15;8(20):3303-6. doi: 10.4161/cc.8.20.9689. Epub 2009 Oct 31. Cell Cycle. 2009. PMID: 19806030

6

Protein Phosphatase 2A as a Therapeutic Target in Small Cell Lung Cancer.

Mirzapoiazova T, Xiao G, Mambetsariev B, Nasser MW, Miaou E, Singhal SS, Srivastava S, Mambetsariev I, Nelson MS, Nam A, Behal A, Arvanitis LD, Atri P, Muschen M, Tissot FLH, Miser J, Kovach JS, Sattler M, Batra SK, Kulkarni P, Salgia R. Mirzapoiazova T, et al. Among authors: kovach js. Mol Cancer Ther. 2021 Oct;20(10):1820-1835. doi: 10.1158/1535-7163.MCT-21-0013. Epub 2021 Jul 12. Mol Cancer Ther. 2021. PMID: 34253596 Free PMC article.

7

Safety, Tolerability, and Preliminary Activity of LB-100, an Inhibitor of Protein Phosphatase 2A, in Patients with Relapsed Solid Tumors: An Open-Label, Dose Escalation, First-in-Human, Phase I Trial.

Chung V, Mansfield AS, Braiteh F, Richards D, Durivage H, Ungerleider RS, Johnson F, Kovach JS. Chung V, et al. Among authors: kovach js. Clin Cancer Res. 2017 Jul 1;23(13):3277-3284. doi: 10.1158/1078-0432.CCR-16-2299. Epub 2016 Dec 30. Clin Cancer Res. 2017. PMID: 28039265

8

Correction: Protein Phosphatase 2A as a Therapeutic Target in Small Cell Lung Cancer.

Mirzapoiazova T, Xiao G, Mambetsariev B, Nasser MW, Miaou E, Singhal SS, Srivastava S, Mambetsariev I, Nelson MS, Nam A, Behal A, Arvanitis LD, Atri P, Muschen M, Tissot FLH, Miser J, Kovach JS, Sattler M, Batra SK, Kulkarni P, Salgia R. Mirzapoiazova T, et al. Among authors: kovach js. Mol Cancer Ther. 2022 Apr 1;21(4):700. doi: 10.1158/1535-7163.MCT-22-0104. Mol Cancer Ther. 2022. PMID: 35373301 Free PMC article. No abstract available.

9

Mutation detection by highly sensitive methods indicates that p53 gene mutations in breast cancer can have important prognostic value.

Kovach JS, Hartmann A, Blaszyk H, Cunningham J, Schaid D, Sommer SS. Kovach JS, et al. Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1093-6. doi: 10.1073/pnas.93.3.1093. Proc Natl Acad Sci U S A. 1996. PMID: 8577720 Free PMC article.

10

Phase I study of difluoromethylornithine in combination with recombinant alpha 2a-interferon.

Edmonson JH, Kovach JS, Buckner JC, Kvols LK, Hahn RG. Edmonson JH, et al. Among authors: kovach js. Cancer Res. 1988 Nov 15;48(22):6584-6. Cancer Res. 1988. PMID: 3141046

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