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The benefits, limitations and opportunities of preclinical models for neonatal drug development.
Campion S, Inselman A, Hayes B, Casiraghi C, Joseph D, Facchinetti F, Salomone F, Schmitt G, Hui J, Davis-Bruno K, Van Malderen K, Morford L, De Schaepdrijver L, Wiesner L, Kourula S, Seo S, Laffan S, Urmaliya V, Chen C. Campion S, et al. Among authors: kourula s. Dis Model Mech. 2022 Apr 1;15(4):dmm049065. doi: 10.1242/dmm.049065. Epub 2022 Apr 25. Dis Model Mech. 2022. PMID: 35466995 Free PMC article. Review.
Gut Microbiome Integration in Drug Discovery and Development of Small Molecules.
Jimonet P, Druart C, Blanquet-Diot S, Boucinha L, Kourula S, Le Vacon F, Maubant S, Rabot S, Van de Wiele T, Schuren F, Thomas V, Walther B, Zimmermann M; Medicen Microbiome Drug Metabolism Working Group. Jimonet P, et al. Among authors: kourula s. Drug Metab Dispos. 2024 Mar 13;52(4):274-287. doi: 10.1124/dmd.123.001605. Drug Metab Dispos. 2024. PMID: 38307852 Review.
Intestinal organoids as an in vitro platform to characterize disposition, metabolism, and safety profile of small molecules.
Kourula S, Derksen M, Jardi F, Jonkers S, van Heerden M, Verboven P, Theuns V, Van Asten S, Huybrechts T, Kunze A, Frazer-Mendelewska E, Lai KW, Overmeer R, Roos JL, Vries RGJ, Boj SF, Monshouwer M, Pourfarzad F, Snoeys J. Kourula S, et al. Eur J Pharm Sci. 2023 Sep 1;188:106481. doi: 10.1016/j.ejps.2023.106481. Epub 2023 May 25. Eur J Pharm Sci. 2023. PMID: 37244450 Free article.
Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state.
Ghazavi F, Huysentruyt J, De Coninck J, Kourula S, Martens S, Hassannia B, Wartewig T, Divert T, Roelandt R, Popper B, Hiergeist A, Tougaard P, Vanden Berghe T, Joossens M, Berx G, Takahashi N, Wahida A, Vandenabeele P. Ghazavi F, et al. Among authors: kourula s. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2024508119. doi: 10.1073/pnas.2024508119. Proc Natl Acad Sci U S A. 2022. PMID: 35105800 Free PMC article.
Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer.
Roberti MP, Yonekura S, Duong CPM, Picard M, Ferrere G, Tidjani Alou M, Rauber C, Iebba V, Lehmann CHK, Amon L, Dudziak D, Derosa L, Routy B, Flament C, Richard C, Daillère R, Fluckiger A, Van Seuningen I, Chamaillard M, Vincent A, Kourula S, Opolon P, Ly P, Pizzato E, Becharef S, Paillet J, Klein C, Marliot F, Pietrantonio F, Benoist S, Scoazec JY, Dartigues P, Hollebecque A, Malka D, Pagès F, Galon J, Gomperts Boneca I, Lepage P, Ryffel B, Raoult D, Eggermont A, Vanden Berghe T, Ghiringhelli F, Vandenabeele P, Kroemer G, Zitvogel L. Roberti MP, et al. Among authors: kourula s. Nat Med. 2020 Jun;26(6):919-931. doi: 10.1038/s41591-020-0882-8. Epub 2020 May 25. Nat Med. 2020. PMID: 32451498 Free article.
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