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NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models.
Sci Transl Med. 2021 Feb 3;13(579):eabb2181. doi: 10.1126/scitranslmed.abb2181.
Sci Transl Med. 2021.
PMID: 33536278
Discovery of 2-oxopiperazine dengue inhibitors by scaffold morphing of a phenotypic high-throughput screening hit.
Kounde CS, Yeo HQ, Wang QY, Wan KF, Dong H, Karuna R, Dix I, Wagner T, Zou B, Simon O, Bonamy GMC, Yeung BKS, Yokokawa F.
Kounde CS, et al.
Bioorg Med Chem Lett. 2017 Mar 15;27(6):1385-1389. doi: 10.1016/j.bmcl.2017.02.005. Epub 2017 Feb 4.
Bioorg Med Chem Lett. 2017.
PMID: 28216045
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Discovery of tetrahydropyrazolopyrimidine carboxamide derivatives as potent and orally active antitubercular agents.
Yokokawa F, Wang G, Chan WL, Ang SH, Wong J, Ma I, Rao SP, Manjunatha U, Lakshminarayana SB, Herve M, Kounde C, Tan BH, Thayalan P, Ng SH, Nanjundappa M, Ravindran S, Gee P, Tan M, Wei L, Goh A, Chen PY, Lee KS, Zhong C, Wagner T, Dix I, Chatterjee AK, Pethe K, Kuhen K, Glynne R, Smith P, Bifani P, Jiricek J.
Yokokawa F, et al.
ACS Med Chem Lett. 2013 Apr 1;4(5):451-5. doi: 10.1021/ml400071a. eCollection 2013 May 9.
ACS Med Chem Lett. 2013.
PMID: 24900693
Free PMC article.
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Photoactive Bifunctional Degraders: Precision Tools To Regulate Protein Stability.
Kounde CS, Tate EW.
Kounde CS, et al.
J Med Chem. 2020 Dec 24;63(24):15483-15493. doi: 10.1021/acs.jmedchem.0c01542. Epub 2020 Nov 23.
J Med Chem. 2020.
PMID: 33226810
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PROTACs, molecular glues and bifunctionals from bench to bedside: Unlocking the clinical potential of catalytic drugs.
Maneiro M, De Vita E, Conole D, Kounde CS, Zhang Q, Tate EW.
Maneiro M, et al. Among authors: kounde cs.
Prog Med Chem. 2021;60:67-190. doi: 10.1016/bs.pmch.2021.01.002. Epub 2021 Mar 27.
Prog Med Chem. 2021.
PMID: 34147206
Review.
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A caged E3 ligase ligand for PROTAC-mediated protein degradation with light.
Kounde CS, Shchepinova MM, Saunders CN, Muelbaier M, Rackham MD, Harling JD, Tate EW.
Kounde CS, et al.
Chem Commun (Camb). 2020 May 21;56(41):5532-5535. doi: 10.1039/d0cc00523a. Epub 2020 Apr 16.
Chem Commun (Camb). 2020.
PMID: 32297626
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Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4.
Maneiro MA, Forte N, Shchepinova MM, Kounde CS, Chudasama V, Baker JR, Tate EW.
Maneiro MA, et al. Among authors: kounde cs.
ACS Chem Biol. 2020 Jun 19;15(6):1306-1312. doi: 10.1021/acschembio.0c00285. Epub 2020 Apr 30.
ACS Chem Biol. 2020.
PMID: 32338867
Free PMC article.
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Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs).
Zhang Q, Kounde CS, Mondal M, Greenfield JL, Baker JR, Kotelnikov S, Ignatov M, Tinworth CP, Zhang L, Conole D, De Vita E, Kozakov D, McCluskey A, Harling JD, Fuchter MJ, Tate EW.
Zhang Q, et al. Among authors: kounde cs.
Chem Commun (Camb). 2022 Sep 29;58(78):10933-10936. doi: 10.1039/d2cc03092f.
Chem Commun (Camb). 2022.
PMID: 36065962
Free PMC article.
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