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Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.
Isobe T, Takagi M, Sato-Otsubo A, Nishimura A, Nagae G, Yamagishi C, Tamura M, Tanaka Y, Asada S, Takeda R, Tsuchiya A, Wang X, Yoshida K, Nannya Y, Ueno H, Akazawa R, Kato I, Mikami T, Watanabe K, Sekiguchi M, Seki M, Kimura S, Hiwatari M, Kato M, Fukuda S, Tatsuno K, Tsutsumi S, Kanai A, Inaba T, Shiozawa Y, Shiraishi Y, Chiba K, Tanaka H, Kotecha RS, Cruickshank MN, Ishikawa F, Morio T, Eguchi M, Deguchi T, Kiyokawa N, Arakawa Y, Koh K, Aoki Y, Ishihara T, Tomizawa D, Miyamura T, Ishii E, Mizutani S, Wilson NK, Göttgens B, Miyano S, Kitamura T, Goyama S, Yokoyama A, Aburatani H, Ogawa S, Takita J. Isobe T, et al. Among authors: kotecha rs. Nat Commun. 2022 Aug 30;13(1):4501. doi: 10.1038/s41467-022-32266-4. Nat Commun. 2022. PMID: 36042201 Free PMC article.
Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin.
Cruickshank MN, Ford J, Cheung LC, Heng J, Singh S, Wells J, Failes TW, Arndt GM, Smithers N, Prinjha RK, Anderson D, Carter KW, Gout AM, Lassmann T, O'Reilly J, Cole CH, Kotecha RS, Kees UR. Cruickshank MN, et al. Among authors: kotecha rs. Leukemia. 2017 Jan;31(1):40-50. doi: 10.1038/leu.2016.165. Epub 2016 Jun 13. Leukemia. 2017. PMID: 27443263 Free PMC article.
Romidepsin enhances the efficacy of cytarabine in vivo, revealing histone deacetylase inhibition as a promising therapeutic strategy for KMT2A-rearranged infant acute lymphoblastic leukemia.
Cheung LC, Cruickshank MN, Hughes AM, Singh S, Chua GA, Ford J, Ferrari E, Oommen J, Malinge S, Lock RB, Kees UR, Kotecha RS. Cheung LC, et al. Among authors: kotecha rs. Haematologica. 2019 Jul;104(7):e300-e303. doi: 10.3324/haematol.2018.192906. Epub 2019 Jan 24. Haematologica. 2019. PMID: 30679330 Free PMC article. No abstract available.
Risk factors for symptomatic venous thromboembolism during therapy for childhood acute lymphoblastic leukemia.
Mateos MK, Trahair TN, Mayoh C, Barbaro PM, Sutton R, Revesz T, Barbaric D, Giles JE, Alvaro F, Mechinaud F, Catchpoole D, Kotecha RS, Dalla-Pozza L, Quinn MCJ, MacGregor S, Chenevix-Trench G, Marshall GM. Mateos MK, et al. Among authors: kotecha rs. Thromb Res. 2019 Jun;178:132-138. doi: 10.1016/j.thromres.2019.04.011. Epub 2019 Apr 11. Thromb Res. 2019. PMID: 31030032
Preclinical efficacy of gemcitabine in MLL-rearranged infant acute lymphoblastic leukemia.
Wander P, Cheung LC, Pinhanҫos SS, Jones L, Kerstjens M, Arentsen-Peters STCJM, Singh S, Chua GA, Castro PG, Schneider P, Dolman MEM, Koopmans B, Molenaar JJ, Pieters R, Zwaan CM, Kotecha RS, Stam RW. Wander P, et al. Among authors: kotecha rs. Leukemia. 2020 Nov;34(11):2898-2902. doi: 10.1038/s41375-020-0895-9. Epub 2020 Jun 2. Leukemia. 2020. PMID: 32488115 No abstract available.
RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia.
Matthijssens F, Sharma ND, Nysus M, Nickl CK, Kang H, Perez DR, Lintermans B, Van Loocke W, Roels J, Peirs S, Demoen L, Pieters T, Reunes L, Lammens T, De Moerloose B, Van Nieuwerburgh F, Deforce DL, Cheung LC, Kotecha RS, Risseeuw MD, Van Calenbergh S, Takarada T, Yoneda Y, van Delft FW, Lock RB, Merkley SD, Chigaev A, Sklar LA, Mullighan CG, Loh ML, Winter SS, Hunger SP, Goossens S, Castillo EF, Ornatowski W, Van Vlierberghe P, Matlawska-Wasowska K. Matthijssens F, et al. Among authors: kotecha rs. J Clin Invest. 2021 Mar 15;131(6):e141566. doi: 10.1172/JCI141566. J Clin Invest. 2021. PMID: 33555272 Free PMC article.
Outcomes for Australian children with relapsed/refractory acute lymphoblastic leukaemia treated with blinatumomab.
Sutton R, Pozza LD, Khaw SL, Fraser C, Revesz T, Chamberlain J, Mitchell R, Trahair TN, Bateman CM, Venn NC, Law T, Ong E, Heatley SL, McClure BJ, Meyer C, Marschalek R, Henderson MJ, Cross S, White DL, Kotecha RS. Sutton R, et al. Among authors: kotecha rs. Pediatr Blood Cancer. 2021 May;68(5):e28922. doi: 10.1002/pbc.28922. Epub 2021 Feb 26. Pediatr Blood Cancer. 2021. PMID: 33638292
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