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A functional variant in MIR4300HG, the host gene of microRNA MIR4300 is associated with progression of adolescent idiopathic scoliosis.
Ogura Y, Kou I, Takahashi Y, Takeda K, Minami S, Kawakami N, Uno K, Ito M, Yonezawa I, Kaito T, Yanagida H, Watanabe K, Taneichi H, Harimaya K, Taniguchi Y, Kotani T, Tsuji T, Suzuki T, Sudo H, Fujita N, Yagi M, Chiba K, Kubo M, Kamatani Y, Nakamura M, Matsumoto M; Japan Scoliosis Clinical Research Group; Watanabe K, Ikegawa S; Japan Scoliosis Clinical Research Group. Ogura Y, et al. Hum Mol Genet. 2017 Oct 15;26(20):4086-4092. doi: 10.1093/hmg/ddx291. Hum Mol Genet. 2017. PMID: 29016859