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Statistical analysis and comparison of a continuous high shear granulator with a twin screw granulator: Effect of process parameters on critical granule attributes and granulation mechanisms.
Int J Pharm. 2016 Nov 20;513(1-2):357-375. doi: 10.1016/j.ijpharm.2016.09.041. Epub 2016 Sep 12.
Int J Pharm. 2016.
PMID: 27633277
A moving-boundary model of dissolution from binary drug-excipient granules incorporating microstructure.
Moroney KM, Kotamarthy L, Muthancheri I, Ramachandran R, Vynnycky M.
Moroney KM, et al. Among authors: kotamarthy l.
Int J Pharm. 2021 Apr 15;599:120219. doi: 10.1016/j.ijpharm.2021.120219. Epub 2021 Feb 4.
Int J Pharm. 2021.
PMID: 33548366
Free article.
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A Semi-Mechanistic Prediction of Residence Time Metrics in Twin Screw Granulation.
Muddu SV, Kotamarthy L, Ramachandran R.
Muddu SV, et al. Among authors: kotamarthy l.
Pharmaceutics. 2021 Mar 16;13(3):393. doi: 10.3390/pharmaceutics13030393.
Pharmaceutics. 2021.
PMID: 33809652
Free PMC article.
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Switching from batch to continuous granulation: A case study of metoprolol succinate ER tablets.
Kotamarthy L, Feng X, Alayoubi A, Kumar Bolla P, Ramachandran R, Ashraf M, O'Connor T, Zidan A.
Kotamarthy L, et al.
Int J Pharm. 2022 Apr 5;617:121598. doi: 10.1016/j.ijpharm.2022.121598. Epub 2022 Feb 22.
Int J Pharm. 2022.
PMID: 35202728
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Optimization of screw design for continuous wet granulation: A case study of metoprolol succinate ER tablets.
Zidan A, Kotamarthy L, Ramachandran R, Ashraf M, O'Connor T.
Zidan A, et al. Among authors: kotamarthy l.
Int J Pharm. 2022 Jul 25;623:121964. doi: 10.1016/j.ijpharm.2022.121964. Epub 2022 Jun 25.
Int J Pharm. 2022.
PMID: 35764264
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Development of a Granule Growth Regime Map for Twin Screw Wet Granulation Process via Data Imputation Techniques.
Kotamarthy L, Sampat C, Ramachandran R.
Kotamarthy L, et al.
Pharmaceutics. 2022 Oct 17;14(10):2211. doi: 10.3390/pharmaceutics14102211.
Pharmaceutics. 2022.
PMID: 36297646
Free PMC article.
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Investigating the Effects of Mixing Dynamics on Twin-Screw Granule Quality Attributes via the Development of a Physics-Based Process Map.
Kotamarthy L, Karkala S, Dan A, Román-Ospino AD, Ramachandran R.
Kotamarthy L, et al.
Pharmaceutics. 2024 Mar 25;16(4):456. doi: 10.3390/pharmaceutics16040456.
Pharmaceutics. 2024.
PMID: 38675117
Free PMC article.
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Optimization of key energy and performance metrics for drug product manufacturing.
Chen Y, Kotamarthy L, Dan A, Sampat C, Bhalode P, Singh R, Glasser BJ, Ramachandran R, Ierapetritou M.
Chen Y, et al. Among authors: kotamarthy l.
Int J Pharm. 2023 Jan 25;631:122487. doi: 10.1016/j.ijpharm.2022.122487. Epub 2022 Dec 13.
Int J Pharm. 2023.
PMID: 36521636
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