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Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis.
Vacca M, Leslie J, Virtue S, Lam BYH, Govaere O, Tiniakos D, Snow S, Davies S, Petkevicius K, Tong Z, Peirce V, Nielsen MJ, Ament Z, Li W, Kostrzewski T, Leeming DJ, Ratziu V, Allison MED, Anstee QM, Griffin JL, Oakley F, Vidal-Puig A. Vacca M, et al. Among authors: kostrzewski t. Nat Metab. 2020 Jun;2(6):514-531. doi: 10.1038/s42255-020-0214-9. Epub 2020 Jun 8. Nat Metab. 2020. PMID: 32694734
A Microphysiological System for Studying Nonalcoholic Steatohepatitis.
Kostrzewski T, Maraver P, Ouro-Gnao L, Levi A, Snow S, Miedzik A, Rombouts K, Hughes D. Kostrzewski T, et al. Hepatol Commun. 2019 Nov 13;4(1):77-91. doi: 10.1002/hep4.1450. eCollection 2020 Jan. Hepatol Commun. 2019. PMID: 31909357 Free PMC article.
Characterizing the reproducibility in using a liver microphysiological system for assaying drug toxicity, metabolism, and accumulation.
Rubiano A, Indapurkar A, Yokosawa R, Miedzik A, Rosenzweig B, Arefin A, Moulin CM, Dame K, Hartman N, Volpe DA, Matta MK, Hughes DJ, Strauss DG, Kostrzewski T, Ribeiro AJS. Rubiano A, et al. Among authors: kostrzewski t. Clin Transl Sci. 2021 May;14(3):1049-1061. doi: 10.1111/cts.12969. Epub 2021 Apr 3. Clin Transl Sci. 2021. PMID: 33382907 Free PMC article.
A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models.
Singh D, Deosarkar SP, Cadogan E, Flemington V, Bray A, Zhang J, Reiserer RS, Schaffer DK, Gerken GB, Britt CM, Werner EM, Gibbons FD, Kostrzewski T, Chambers CE, Davies EJ, Montoya AR, Fok JHL, Hughes D, Fabre K, Wagoner MP, Wikswo JP, Scott CW. Singh D, et al. Among authors: kostrzewski t. PLoS Biol. 2022 May 26;20(5):e3001624. doi: 10.1371/journal.pbio.3001624. eCollection 2022 May. PLoS Biol. 2022. PMID: 35617197 Free PMC article.
14 results