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A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells.
ACS Chem Biol. 2021 Apr 16;16(4):642-650. doi: 10.1021/acschembio.0c00875. Epub 2021 Mar 31.
ACS Chem Biol. 2021.
PMID: 33787221
A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells.
Mellott DM, Tseng CT, Drelich A, Fajtová P, Chenna BC, Kostomiris DH, Hsu J, Zhu J, Taylor ZW, Tat V, Katzfuss A, Li L, Giardini MA, Skinner D, Hirata K, Beck S, Carlin AF, Clark AE, Beretta L, Maneval D, Frueh F, Hurst BL, Wang H, Kocurek KI, Raushel FM, O'Donoghue AJ, de Siqueira-Neto JL, Meek TD, McKerrow JH.
Mellott DM, et al. Among authors: kostomiris dh.
bioRxiv [Preprint]. 2020 Oct 30:2020.10.23.347534. doi: 10.1101/2020.10.23.347534.
bioRxiv. 2020.
PMID: 33140046
Free PMC article.
Updated.
Preprint.
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Kinetic Characterization and Inhibition of Trypanosoma cruzi Hypoxanthine-Guanine Phosphoribosyltransferases.
Glockzin K, Kostomiris D, Minnow YVT, Suthagar K, Clinch K, Gai S, Buckler JN, Schramm VL, Tyler PC, Meek TD, Katzfuss A.
Glockzin K, et al.
Biochemistry. 2022 Oct 4;61(19):2088-2105. doi: 10.1021/acs.biochem.2c00312. Epub 2022 Sep 15.
Biochemistry. 2022.
PMID: 36193631
Free PMC article.
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Dissecting the Kinetic Mechanism of Human Lysine Methyltransferase 2D and Its Interactions with the WRAD2 Complex.
Edwardes LV, Caswell SJ, Giurrandino M, Zhai X, Gohlke A, Kostomiris DH, Pollard HK, Pflug A, Hamm GR, Jervis KV, Clarkson PN, Syson K.
Edwardes LV, et al. Among authors: kostomiris dh.
Biochemistry. 2022 Sep 20;61(18):1974-1987. doi: 10.1021/acs.biochem.2c00385. Epub 2022 Sep 7.
Biochemistry. 2022.
PMID: 36070615
Free PMC article.
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