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Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability.
Burrows SR, Chen Z, Archbold JK, Tynan FE, Beddoe T, Kjer-Nielsen L, Miles JJ, Khanna R, Moss DJ, Liu YC, Gras S, Kostenko L, Brennan RM, Clements CS, Brooks AG, Purcell AW, McCluskey J, Rossjohn J. Burrows SR, et al. Among authors: kostenko l. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10608-13. doi: 10.1073/pnas.1004926107. Epub 2010 May 18. Proc Natl Acad Sci U S A. 2010. PMID: 20483993 Free PMC article.
Immune self-reactivity triggered by drug-modified HLA-peptide repertoire.
Illing PT, Vivian JP, Dudek NL, Kostenko L, Chen Z, Bharadwaj M, Miles JJ, Kjer-Nielsen L, Gras S, Williamson NA, Burrows SR, Purcell AW, Rossjohn J, McCluskey J. Illing PT, et al. Among authors: kostenko l. Nature. 2012 Jun 28;486(7404):554-8. doi: 10.1038/nature11147. Nature. 2012. PMID: 22722860
MR1 presents microbial vitamin B metabolites to MAIT cells.
Kjer-Nielsen L, Patel O, Corbett AJ, Le Nours J, Meehan B, Liu L, Bhati M, Chen Z, Kostenko L, Reantragoon R, Williamson NA, Purcell AW, Dudek NL, McConville MJ, O'Hair RA, Khairallah GN, Godfrey DI, Fairlie DP, Rossjohn J, McCluskey J. Kjer-Nielsen L, et al. Among authors: kostenko l. Nature. 2012 Nov 29;491(7426):717-23. doi: 10.1038/nature11605. Epub 2012 Oct 10. Nature. 2012. PMID: 23051753
Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.
Keller AN, Eckle SB, Xu W, Liu L, Hughes VA, Mak JY, Meehan BS, Pediongco T, Birkinshaw RW, Chen Z, Wang H, D'Souza C, Kjer-Nielsen L, Gherardin NA, Godfrey DI, Kostenko L, Corbett AJ, Purcell AW, Fairlie DP, McCluskey J, Rossjohn J. Keller AN, et al. Among authors: kostenko l. Nat Immunol. 2017 Apr;18(4):402-411. doi: 10.1038/ni.3679. Epub 2017 Feb 6. Nat Immunol. 2017. PMID: 28166217
73 results