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Gene amplifications cause high-level resistance against albicidin in gram-negative bacteria.
Saathoff M, Kosol S, Semmler T, Tedin K, Dimos N, Kupke J, Seidel M, Ghazisaeedi F, Jonske MC, Wolf SA, Kuropka B, Czyszczoń W, Ghilarov D, Grätz S, Heddle JG, Loll B, Süssmuth RD, Fulde M. Saathoff M, et al. Among authors: kosol s. PLoS Biol. 2023 Aug 10;21(8):e3002186. doi: 10.1371/journal.pbio.3002186. eCollection 2023 Aug. PLoS Biol. 2023. PMID: 37561817 Free PMC article.
Discovery of the Lanthipeptide Curvocidin and Structural Insights into its Trifunctional Synthetase CuvL.
Sigurdsson A, Martins BM, Düttmann SA, Jasyk M, Dimos-Röhl B, Schöpf F, Gemander M, Knittel CH, Schnegotzki R, Schmid B, Kosol S, Pommerening L, Gonzáles-Viegaz M, Seidel M, Hügelland M, Leimkühler S, Dobbek H, Mainz A, Süssmuth RD. Sigurdsson A, et al. Among authors: kosol s. Angew Chem Int Ed Engl. 2023 Jun 5;62(23):e202302490. doi: 10.1002/anie.202302490. Epub 2023 Apr 27. Angew Chem Int Ed Engl. 2023. PMID: 37014271
The occurrence of ansamers in the synthesis of cyclic peptides.
Yao G, Kosol S, Wenz MT, Irran E, Keller BG, Trapp O, Süssmuth RD. Yao G, et al. Among authors: kosol s. Nat Commun. 2022 Oct 30;13(1):6488. doi: 10.1038/s41467-022-34125-8. Nat Commun. 2022. PMID: 36310176 Free PMC article.
The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl-Acyl Carrier Protein Binding Site of FabI.
Fage CD, Lathouwers T, Vanmeert M, Gao LJ, Vrancken K, Lammens EM, Weir ANM, Degroote R, Cuppens H, Kosol S, Simpson TJ, Crump MP, Willis CL, Herdewijn P, Lescrinier E, Lavigne R, Anné J, Masschelein J. Fage CD, et al. Among authors: kosol s. Angew Chem Int Ed Engl. 2020 Jun 22;59(26):10549-10556. doi: 10.1002/anie.201915407. Epub 2020 Apr 14. Angew Chem Int Ed Engl. 2020. PMID: 32208550
Structural basis for chain release from the enacyloxin polyketide synthase.
Kosol S, Gallo A, Griffiths D, Valentic TR, Masschelein J, Jenner M, de Los Santos ELC, Manzi L, Sydor PK, Rea D, Zhou S, Fülöp V, Oldham NJ, Tsai SC, Challis GL, Lewandowski JR. Kosol S, et al. Nat Chem. 2019 Oct;11(10):913-923. doi: 10.1038/s41557-019-0335-5. Epub 2019 Sep 23. Nat Chem. 2019. PMID: 31548674 Free PMC article.
32 results