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Structural basis for chain release from the enacyloxin polyketide synthase.
Kosol S, Gallo A, Griffiths D, Valentic TR, Masschelein J, Jenner M, de Los Santos ELC, Manzi L, Sydor PK, Rea D, Zhou S, Fülöp V, Oldham NJ, Tsai SC, Challis GL, Lewandowski JR. Kosol S, et al. Nat Chem. 2019 Oct;11(10):913-923. doi: 10.1038/s41557-019-0335-5. Epub 2019 Sep 23. Nat Chem. 2019. PMID: 31548674 Free PMC article.
A cation-π interaction in a transmembrane helix of vacuolar ATPase retains the proton-transporting arginine in a hydrophobic environment.
Hohlweg W, Wagner GE, Hofbauer HF, Sarkleti F, Setz M, Gubensäk N, Lichtenegger S, Falsone SF, Wolinski H, Kosol S, Oostenbrink C, Kohlwein SD, Zangger K. Hohlweg W, et al. Among authors: kosol s. J Biol Chem. 2018 Dec 7;293(49):18977-18988. doi: 10.1074/jbc.RA118.005276. Epub 2018 Sep 12. J Biol Chem. 2018. PMID: 30209131 Free PMC article.
The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl-Acyl Carrier Protein Binding Site of FabI.
Fage CD, Lathouwers T, Vanmeert M, Gao LJ, Vrancken K, Lammens EM, Weir ANM, Degroote R, Cuppens H, Kosol S, Simpson TJ, Crump MP, Willis CL, Herdewijn P, Lescrinier E, Lavigne R, Anné J, Masschelein J. Fage CD, et al. Among authors: kosol s. Angew Chem Int Ed Engl. 2020 Jun 22;59(26):10549-10556. doi: 10.1002/anie.201915407. Epub 2020 Apr 14. Angew Chem Int Ed Engl. 2020. PMID: 32208550
Flexible IgE epitope-containing domains of Phl p 5 cause high allergenic activity.
Göbl C, Focke-Tejkl M, Najafi N, Schrank E, Madl T, Kosol S, Madritsch C, Dorofeeva Y, Flicker S, Thalhamer J, Valenta R, Zangger K, Tjandra N. Göbl C, et al. Among authors: kosol s. J Allergy Clin Immunol. 2017 Oct;140(4):1187-1191. doi: 10.1016/j.jaci.2017.05.005. Epub 2017 May 19. J Allergy Clin Immunol. 2017. PMID: 28532654 Free PMC article.
32 results