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Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration.
Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M, Leinonen H, Tanila H, Kivinen N, Koistinen A, Toropainen E, Amadio M, Smedowski A, Reinisalo M, Winiarczyk M, Mackiewicz J, Mutikainen M, Ruotsalainen AK, Kettunen M, Jokivarsi K, Sinha D, Kinnunen K, Petrovski G, Blasiak J, Bjørkøy G, Koskelainen A, Skottman H, Urtti A, Salminen A, Kannan R, Ferrington DA, Xu H, Levonen AL, Tavi P, Kauppinen A, Kaarniranta K. Felszeghy S, et al. Among authors: koskelainen a. Redox Biol. 2019 Jan;20:1-12. doi: 10.1016/j.redox.2018.09.011. Epub 2018 Sep 14. Redox Biol. 2019. PMID: 30253279 Free PMC article.
Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice.
Tamminen T, Koskela A, Toropainen E, Gurubaran IS, Winiarczyk M, Liukkonen M, Paterno JJ, Lackman P, Sadeghi A, Viiri J, Hyttinen JMT, Koskelainen A, Kaarniranta K. Tamminen T, et al. Among authors: koskelainen a. Oxid Med Cell Longev. 2021 Dec 7;2021:8028427. doi: 10.1155/2021/8028427. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 34917233 Free PMC article. Retracted.
Lack of P4H-TM in mice results in age-related retinal and renal alterations.
Leinonen H, Rossi M, Salo AM, Tiainen P, Hyvärinen J, Pitkänen M, Sormunen R, Miinalainen I, Zhang C, Soininen R, Kivirikko KI, Koskelainen A, Tanila H, Myllyharju J, Koivunen P. Leinonen H, et al. Among authors: koskelainen a. Hum Mol Genet. 2016 Sep 1;25(17):3810-3823. doi: 10.1093/hmg/ddw228. Epub 2016 Jul 27. Hum Mol Genet. 2016. PMID: 27466183
42 results