Kosjek B - Search Results

1

Synthesis of bis-macrocyclic HCV protease inhibitor MK-6325 via intramolecular sp²-sp³ Suzuki-Miyaura coupling and ring closing metathesis.

Li H, Scott JP, Chen CY, Journet M, Belyk K, Balsells J, Kosjek B, Baxter CA, Stewart GW, Wise C, Alam M, Song ZJ, Tan L. Li H, et al. Among authors: kosjek b. Org Lett. 2015 Mar 20;17(6):1533-6. doi: 10.1021/acs.orglett.5b00418. Epub 2015 Mar 10. Org Lett. 2015. PMID: 25754231

2

Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction.

Hyde AM, Liu Z, Kosjek B, Tan L, Klapars A, Ashley ER, Zhong YL, Alvizo O, Agard NJ, Liu G, Gu X, Yasuda N, Limanto J, Huffman MA, Tschaen DM. Hyde AM, et al. Among authors: kosjek b. Org Lett. 2016 Nov 18;18(22):5888-5891. doi: 10.1021/acs.orglett.6b02910. Epub 2016 Nov 1. Org Lett. 2016. PMID: 27802043

3

Scalable Asymmetric Synthesis of MK-8998, a T-Type Calcium Channel Antagonist.

Zhong YL, Moore JC, Shevlin M, Shultz CS, Kosjek B, Chen Y, Janey JM, Tan L. Zhong YL, et al. Among authors: kosjek b. J Org Chem. 2022 Feb 18;87(4):2120-2128. doi: 10.1021/acs.joc.1c01795. Epub 2021 Sep 28. J Org Chem. 2022. PMID: 34582192

4

Chemo- and enantioselective routes to chiral fluorinated hydroxyketones using ketoreductases.

Grau BT, Devine PN, DiMichele LN, Kosjek B. Grau BT, et al. Among authors: kosjek b. Org Lett. 2007 Nov 22;9(24):4951-4. doi: 10.1021/ol701810v. Epub 2007 Oct 31. Org Lett. 2007. PMID: 17973397

5

CRTH2 antagonist MK-7246: a synthetic evolution from discovery through development.

Molinaro C, Bulger PG, Lee EE, Kosjek B, Lau S, Gauvreau D, Howard ME, Wallace DJ, O'Shea PD. Molinaro C, et al. Among authors: kosjek b. J Org Chem. 2012 Mar 2;77(5):2299-309. doi: 10.1021/jo202620r. Epub 2012 Feb 15. J Org Chem. 2012. PMID: 22335767

6

Resolution of 2,2-disubstituted epoxides via biocatalytic azidolysis.

Molinaro C, Guilbault AA, Kosjek B. Molinaro C, et al. Among authors: kosjek b. Org Lett. 2010 Sep 3;12(17):3772-5. doi: 10.1021/ol101406k. Org Lett. 2010. PMID: 20681610

7

Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases.

Gallant M, Beaulieu C, Berthelette C, Colucci J, Crackower MA, Dalton C, Denis D, Ducharme Y, Friesen RW, Guay D, Gervais FG, Hamel M, Houle R, Krawczyk CM, Kosjek B, Lau S, Leblanc Y, Lee EE, Levesque JF, Mellon C, Molinaro C, Mullet W, O'Neill GP, O'Shea P, Sawyer N, Sillaots S, Simard D, Slipetz D, Stocco R, Sørensen D, Truong VL, Wong E, Wu J, Zaghdane H, Wang Z. Gallant M, et al. Among authors: kosjek b. Bioorg Med Chem Lett. 2011 Jan 1;21(1):288-93. doi: 10.1016/j.bmcl.2010.11.015. Epub 2010 Nov 5. Bioorg Med Chem Lett. 2011. PMID: 21106375

8

Synthesis of Vibegron Enabled by a Ketoreductase Rationally Designed for High pH Dynamic Kinetic Reduction.

Xu F, Kosjek B, Cabirol FL, Chen H, Desmond R, Park J, Gohel AP, Collier SJ, Smith DJ, Liu Z, Janey JM, Chung JYL, Alvizo O. Xu F, et al. Among authors: kosjek b. Angew Chem Int Ed Engl. 2018 Jun 4;57(23):6863-6867. doi: 10.1002/anie.201802791. Epub 2018 May 3. Angew Chem Int Ed Engl. 2018. PMID: 29689604

9

Advances in the enzymatic reduction of ketones.

Moore JC, Pollard DJ, Kosjek B, Devine PN. Moore JC, et al. Among authors: kosjek b. Acc Chem Res. 2007 Dec;40(12):1412-9. doi: 10.1021/ar700167a. Epub 2007 Dec 4. Acc Chem Res. 2007. PMID: 18052114 Review.

10

Biocatalytic asymmetric hydrogen transfer employing Rhodococcus ruber DSM 44541.

Stampfer W, Kosjek B, Faber K, Kroutil W. Stampfer W, et al. Among authors: kosjek b. J Org Chem. 2003 Jan 24;68(2):402-6. doi: 10.1021/jo026216w. J Org Chem. 2003. PMID: 12530865

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