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Tapping a bacterial enzymatic pathway for the preparation and manipulation of synthetic nanomaterials.
J Am Chem Soc. 2014 Dec 17;136(50):17378-81. doi: 10.1021/ja509827s. Epub 2014 Dec 3.
J Am Chem Soc. 2014.
PMID: 25468257
Free PMC article.
Fluorescent techniques for discovery and characterization of phosphopantetheinyl transferase inhibitors.
Kosa NM, Foley TL, Burkart MD.
Kosa NM, et al.
J Antibiot (Tokyo). 2014 Jan;67(1):113-20. doi: 10.1038/ja.2013.106. Epub 2013 Nov 6.
J Antibiot (Tokyo). 2014.
PMID: 24192555
Free PMC article.
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Structure, biochemistry, and inhibition of essential 4'-phosphopantetheinyl transferases from two species of Mycobacteria.
Vickery CR, Kosa NM, Casavant EP, Duan S, Noel JP, Burkart MD.
Vickery CR, et al. Among authors: kosa nm.
ACS Chem Biol. 2014 Sep 19;9(9):1939-44. doi: 10.1021/cb500263p. Epub 2014 Jul 9.
ACS Chem Biol. 2014.
PMID: 24963544
Free PMC article.
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Chemoenzymatic exchange of phosphopantetheine on protein and peptide.
Kosa NM, Pham KM, Burkart MD.
Kosa NM, et al.
Chem Sci. 2014 Mar 1;5(3):1179-1186. doi: 10.1039/C3SC53154F. Epub 2014 Jan 2.
Chem Sci. 2014.
PMID: 26998215
Free PMC article.
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Discovering de novo peptide substrates for enzymes using machine learning.
Tallorin L, Wang J, Kim WE, Sahu S, Kosa NM, Yang P, Thompson M, Gilson MK, Frazier PI, Burkart MD, Gianneschi NC.
Tallorin L, et al. Among authors: kosa nm.
Nat Commun. 2018 Dec 7;9(1):5253. doi: 10.1038/s41467-018-07717-6.
Nat Commun. 2018.
PMID: 30531862
Free PMC article.
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Reversible labeling of native and fusion-protein motifs.
Kosa NM, Haushalter RW, Smith AR, Burkart MD.
Kosa NM, et al.
Nat Methods. 2012 Oct;9(10):981-4. doi: 10.1038/nmeth.2175. Epub 2012 Sep 16.
Nat Methods. 2012.
PMID: 22983458
Free PMC article.
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Resin supported acyl carrier protein labeling strategies.
Rothmann M, Kosa NM, Burkart MD.
Rothmann M, et al. Among authors: kosa nm.
RSC Adv. 2014;4(18):9092-9097. doi: 10.1039/C3RA47847E.
RSC Adv. 2014.
PMID: 24818001
Free PMC article.
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4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth.
Foley TL, Rai G, Yasgar A, Daniel T, Baker HL, Attene-Ramos M, Kosa NM, Leister W, Burkart MD, Jadhav A, Simeonov A, Maloney DJ.
Foley TL, et al. Among authors: kosa nm.
J Med Chem. 2014 Feb 13;57(3):1063-78. doi: 10.1021/jm401752p. Epub 2014 Jan 22.
J Med Chem. 2014.
PMID: 24450337
Free PMC article.
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