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Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response.
Salvagno C, Ciampricotti M, Tuit S, Hau CS, van Weverwijk A, Coffelt SB, Kersten K, Vrijland K, Kos K, Ulas T, Song JY, Ooi CH, Rüttinger D, Cassier PA, Jonkers J, Schultze JL, Ries CH, de Visser KE. Salvagno C, et al. Among authors: kos k. Nat Cell Biol. 2019 Apr;21(4):511-521. doi: 10.1038/s41556-019-0298-1. Epub 2019 Mar 18. Nat Cell Biol. 2019. PMID: 30886344 Free PMC article.
Neutrophils create a fertile soil for metastasis.
Kos K, de Visser KE. Kos K, et al. Cancer Cell. 2021 Mar 8;39(3):301-303. doi: 10.1016/j.ccell.2021.01.009. Epub 2021 Jan 28. Cancer Cell. 2021. PMID: 33513347 Free article.
Pro-mutagenic effects of the gut microbiota in a Lynch syndrome mouse model.
Pieters W, Hugenholtz F, Kos K, Cammeraat M, Moliej TC, Kaldenbach D, Klarenbeek S, Davids M, Drost L, de Konink C, Delzenne-Goette E, de Visser KE, Te Riele H. Pieters W, et al. Among authors: kos k. Gut Microbes. 2022 Jan-Dec;14(1):2035660. doi: 10.1080/19490976.2022.2035660. Gut Microbes. 2022. PMID: 35188867 Free PMC article.
IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer.
Blomberg OS, Spagnuolo L, Garner H, Voorwerk L, Isaeva OI, van Dyk E, Bakker N, Chalabi M, Klaver C, Duijst M, Kersten K, Brüggemann M, Pastoors D, Hau CS, Vrijland K, Raeven EAM, Kaldenbach D, Kos K, Afonina IS, Kaptein P, Hoes L, Theelen WSME, Baas P, Voest EE, Beyaert R, Thommen DS, Wessels LFA, de Visser KE, Kok M. Blomberg OS, et al. Among authors: kos k. Cancer Cell. 2023 Jan 9;41(1):106-123.e10. doi: 10.1016/j.ccell.2022.11.014. Epub 2022 Dec 15. Cancer Cell. 2023. PMID: 36525971 Free article.
Neoadjuvant immune checkpoint blockade triggers persistent and systemic Treg activation which blunts therapeutic efficacy against metastatic spread of breast tumors.
Blomberg OS, Kos K, Spagnuolo L, Isaeva OI, Garner H, Wellenstein MD, Bakker N, Duits DEM, Kersten K, Klarenbeek S, Hau CS, Kaldenbach D, Raeven EAM, Vrijland K, Kok M, de Visser KE. Blomberg OS, et al. Among authors: kos k. Oncoimmunology. 2023 Apr 13;12(1):2201147. doi: 10.1080/2162402X.2023.2201147. eCollection 2023. Oncoimmunology. 2023. PMID: 37089449 Free PMC article.
NK cell heparanase controls tumor invasion and immune surveillance.
Putz EM, Mayfosh AJ, Kos K, Barkauskas DS, Nakamura K, Town L, Goodall KJ, Yee DY, Poon IK, Baschuk N, Souza-Fonseca-Guimaraes F, Hulett MD, Smyth MJ. Putz EM, et al. Among authors: kos k. J Clin Invest. 2017 Jun 30;127(7):2777-2788. doi: 10.1172/JCI92958. Epub 2017 Jun 5. J Clin Invest. 2017. PMID: 28581441 Free PMC article.
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