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PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation.
Iannotta L, Emanuele M, Favetta G, Tombesi G, Vandewynckel L, Lara Ordóñez AJ, Saliou JM, Drouyer M, Sibran W, Civiero L, Nichols RJ, Athanasopoulos PS, Kortholt A, Chartier-Harlin MC, Greggio E, Taymans JM. Iannotta L, et al. Among authors: kortholt a. Front Mol Neurosci. 2023 Dec 18;16:1269387. doi: 10.3389/fnmol.2023.1269387. eCollection 2023. Front Mol Neurosci. 2023. PMID: 38169846 Free PMC article.
Editorial: LRRK2-Fifteen Years From Cloning to the Clinic.
Rideout H, Greggio E, Kortholt A, Nichols RJ. Rideout H, et al. Among authors: kortholt a. Front Neurosci. 2022 Apr 11;16:880914. doi: 10.3389/fnins.2022.880914. eCollection 2022. Front Neurosci. 2022. PMID: 35478845 Free PMC article. No abstract available.
The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation.
Cogo S, Ho FY, Tosoni E, Tomkins JE, Tessari I, Iannotta L, Montine TJ, Manzoni C, Lewis PA, Bubacco L, Chartier Harlin MC, Taymans JM, Kortholt A, Nichols J, Cendron L, Civiero L, Greggio E. Cogo S, et al. Among authors: kortholt a. Brain Res. 2022 Mar 1;1778:147781. doi: 10.1016/j.brainres.2022.147781. Epub 2022 Jan 10. Brain Res. 2022. PMID: 35016853
A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively.
Marchand A, Sarchione A, Athanasopoulos PS, Roy HB, Goveas L, Magnez R, Drouyer M, Emanuele M, Ho FY, Liberelle M, Melnyk P, Lebègue N, Thuru X, Nichols RJ, Greggio E, Kortholt A, Galli T, Chartier-Harlin MC, Taymans JM. Marchand A, et al. Among authors: kortholt a. Cells. 2022 Mar 17;11(6):1018. doi: 10.3390/cells11061018. Cells. 2022. PMID: 35326469 Free PMC article.
Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides.
Helton LG, Soliman A, von Zweydorf F, Kentros M, Manschwetus JT, Hall S, Gilsbach B, Ho FY, Athanasopoulos PS, Singh RK, LeClair TJ, Versées W, Raimondi F, Herberg FW, Gloeckner CJ, Rideout H, Kortholt A, Kennedy EJ. Helton LG, et al. Among authors: kortholt a. ACS Chem Biol. 2021 Nov 19;16(11):2326-2338. doi: 10.1021/acschembio.1c00487. Epub 2021 Sep 8. ACS Chem Biol. 2021. PMID: 34496561 Free article.
Biochemical and kinetic properties of the complex Roco G-protein cycle.
Wauters L, Terheyden S, Gilsbach BK, Leemans M, Athanasopoulos PS, Guaitoli G, Wittinghofer A, Gloeckner CJ, Versées W, Kortholt A. Wauters L, et al. Among authors: kortholt a. Biol Chem. 2018 Nov 27;399(12):1447-1456. doi: 10.1515/hsz-2018-0227. Biol Chem. 2018. PMID: 30067506
A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover.
Deyaert E, Wauters L, Guaitoli G, Konijnenberg A, Leemans M, Terheyden S, Petrovic A, Gallardo R, Nederveen-Schippers LM, Athanasopoulos PS, Pots H, Van Haastert PJM, Sobott F, Gloeckner CJ, Efremov R, Kortholt A, Versées W. Deyaert E, et al. Among authors: kortholt a. Nat Commun. 2017 Oct 18;8(1):1008. doi: 10.1038/s41467-017-01103-4. Nat Commun. 2017. PMID: 29044096 Free PMC article.
73 results