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Editorial: LRRK2-Fifteen Years From Cloning to the Clinic.
Rideout H, Greggio E, Kortholt A, Nichols RJ. Rideout H, et al. Among authors: kortholt a. Front Neurosci. 2022 Apr 11;16:880914. doi: 10.3389/fnins.2022.880914. eCollection 2022. Front Neurosci. 2022. PMID: 35478845 Free PMC article. No abstract available.
Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides.
Helton LG, Soliman A, von Zweydorf F, Kentros M, Manschwetus JT, Hall S, Gilsbach B, Ho FY, Athanasopoulos PS, Singh RK, LeClair TJ, Versées W, Raimondi F, Herberg FW, Gloeckner CJ, Rideout H, Kortholt A, Kennedy EJ. Helton LG, et al. Among authors: kortholt a. ACS Chem Biol. 2021 Nov 19;16(11):2326-2338. doi: 10.1021/acschembio.1c00487. Epub 2021 Sep 8. ACS Chem Biol. 2021. PMID: 34496561 Free article.
The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation.
Cogo S, Ho FY, Tosoni E, Tomkins JE, Tessari I, Iannotta L, Montine TJ, Manzoni C, Lewis PA, Bubacco L, Chartier Harlin MC, Taymans JM, Kortholt A, Nichols J, Cendron L, Civiero L, Greggio E. Cogo S, et al. Among authors: kortholt a. Brain Res. 2022 Mar 1;1778:147781. doi: 10.1016/j.brainres.2022.147781. Epub 2022 Jan 10. Brain Res. 2022. PMID: 35016853
A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively.
Marchand A, Sarchione A, Athanasopoulos PS, Roy HB, Goveas L, Magnez R, Drouyer M, Emanuele M, Ho FY, Liberelle M, Melnyk P, Lebègue N, Thuru X, Nichols RJ, Greggio E, Kortholt A, Galli T, Chartier-Harlin MC, Taymans JM. Marchand A, et al. Among authors: kortholt a. Cells. 2022 Mar 17;11(6):1018. doi: 10.3390/cells11061018. Cells. 2022. PMID: 35326469 Free PMC article.
Doubly Constrained C-terminal of Roc (COR) Domain-Derived Peptides Inhibit Leucine-Rich Repeat Kinase 2 (LRRK2) Dimerization.
Pathak P, Alexander KK, Helton LG, Kentros M, LeClair TJ, Zhang X, Ho FY, Moore TT, Hall S, Guaitoli G, Gloeckner CJ, Kortholt A, Rideout H, Kennedy EJ. Pathak P, et al. Among authors: kortholt a. ACS Chem Neurosci. 2023 Jun 7;14(11):1971-1980. doi: 10.1021/acschemneuro.3c00259. Epub 2023 May 18. ACS Chem Neurosci. 2023. PMID: 37200505 Free PMC article.
PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation.
Iannotta L, Emanuele M, Favetta G, Tombesi G, Vandewynckel L, Lara Ordóñez AJ, Saliou JM, Drouyer M, Sibran W, Civiero L, Nichols RJ, Athanasopoulos PS, Kortholt A, Chartier-Harlin MC, Greggio E, Taymans JM. Iannotta L, et al. Among authors: kortholt a. Front Mol Neurosci. 2023 Dec 18;16:1269387. doi: 10.3389/fnmol.2023.1269387. eCollection 2023. Front Mol Neurosci. 2023. PMID: 38169846 Free PMC article.
Allosteric inhibition of LRRK2, where are we now.
Soliman A, Cankara FN, Kortholt A. Soliman A, et al. Among authors: kortholt a. Biochem Soc Trans. 2020 Oct 30;48(5):2185-2194. doi: 10.1042/BST20200424. Biochem Soc Trans. 2020. PMID: 33079169 Free PMC article. Review.
73 results