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The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties.
Caldarone BJ, Paterson NE, Zhou J, Brunner D, Kozikowski AP, Westphal KG, Korte-Bouws GA, Prins J, Korte SM, Olivier B, Ghavami A. Caldarone BJ, et al. Among authors: korte bouws ga, korte sm. J Pharmacol Exp Ther. 2010 Dec;335(3):762-70. doi: 10.1124/jpet.110.174011. Epub 2010 Sep 23. J Pharmacol Exp Ther. 2010. PMID: 20864506 Free PMC article.
Lipopolysaccharide increases degradation of central monoamines: an in vivo microdialysis study in the nucleus accumbens and medial prefrontal cortex of mice.
van Heesch F, Prins J, Konsman JP, Korte-Bouws GA, Westphal KG, Rybka J, Olivier B, Kraneveld AD, Korte SM. van Heesch F, et al. Among authors: korte bouws ga, korte sm. Eur J Pharmacol. 2014 Feb 15;725:55-63. doi: 10.1016/j.ejphar.2014.01.014. Epub 2014 Jan 17. Eur J Pharmacol. 2014. PMID: 24444442
The 5-HT1A/1B-receptor agonist eltoprazine increases both catecholamine release in the prefrontal cortex and dopamine release in the nucleus accumbens and decreases motivation for reward and "waiting" impulsivity, but increases "stopping" impulsivity.
Korte SM, Prins J, Van den Bergh FS, Oosting RS, Dupree R, Korte-Bouws GA, Westphal KG, Olivier B, Denys DA, Garland A, Güntürkün O. Korte SM, et al. Eur J Pharmacol. 2017 Jan 5;794:257-269. doi: 10.1016/j.ejphar.2016.11.024. Epub 2016 Nov 17. Eur J Pharmacol. 2017. PMID: 27866999
The triple monoaminergic reuptake inhibitor DOV 216,303 has antidepressant effects in the rat olfactory bulbectomy model and lacks sexual side effects.
Breuer ME, Chan JS, Oosting RS, Groenink L, Korte SM, Campbell U, Schreiber R, Hanania T, Snoeren EM, Waldinger M, Olivier B. Breuer ME, et al. Among authors: korte sm. Eur Neuropsychopharmacol. 2008 Dec;18(12):908-16. doi: 10.1016/j.euroneuro.2008.07.011. Epub 2008 Sep 11. Eur Neuropsychopharmacol. 2008. PMID: 18789657
108 results