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Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenotype.
Steubler V, Erdinger S, Back MK, Ludewig S, Fässler D, Richter M, Han K, Slomianka L, Amrein I, von Engelhardt J, Wolfer DP, Korte M, Müller UC. Steubler V, et al. Among authors: korte m. EMBO J. 2021 Jun 15;40(12):e107471. doi: 10.15252/embj.2020107471. Epub 2021 May 19. EMBO J. 2021. PMID: 34008862 Free PMC article.
Essential role for TrkB receptors in hippocampus-mediated learning.
Minichiello L, Korte M, Wolfer D, Kühn R, Unsicker K, Cestari V, Rossi-Arnaud C, Lipp HP, Bonhoeffer T, Klein R. Minichiello L, et al. Among authors: korte m. Neuron. 1999 Oct;24(2):401-14. doi: 10.1016/s0896-6273(00)80853-3. Neuron. 1999. PMID: 10571233 Free article.
The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.
Ring S, Weyer SW, Kilian SB, Waldron E, Pietrzik CU, Filippov MA, Herms J, Buchholz C, Eckman CB, Korte M, Wolfer DP, Müller UC. Ring S, et al. Among authors: korte m. J Neurosci. 2007 Jul 18;27(29):7817-26. doi: 10.1523/JNEUROSCI.1026-07.2007. J Neurosci. 2007. PMID: 17634375 Free PMC article.
APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP.
Weyer SW, Klevanski M, Delekate A, Voikar V, Aydin D, Hick M, Filippov M, Drost N, Schaller KL, Saar M, Vogt MA, Gass P, Samanta A, Jäschke A, Korte M, Wolfer DP, Caldwell JH, Müller UC. Weyer SW, et al. Among authors: korte m. EMBO J. 2011 Jun 1;30(11):2266-80. doi: 10.1038/emboj.2011.119. Epub 2011 Apr 26. EMBO J. 2011. PMID: 21522131 Free PMC article.
Hippocampal network oscillations in APP/APLP2-deficient mice.
Zhang X, Herrmann U, Weyer SW, Both M, Müller UC, Korte M, Draguhn A. Zhang X, et al. Among authors: korte m. PLoS One. 2013 Apr 9;8(4):e61198. doi: 10.1371/journal.pone.0061198. Print 2013. PLoS One. 2013. PMID: 23585881 Free PMC article.
243 results