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EGFR oligomerization organizes kinase-active dimers into competent signalling platforms.
Needham SR, Roberts SK, Arkhipov A, Mysore VP, Tynan CJ, Zanetti-Domingues LC, Kim ET, Losasso V, Korovesis D, Hirsch M, Rolfe DJ, Clarke DT, Winn MD, Lajevardipour A, Clayton AH, Pike LJ, Perani M, Parker PJ, Shan Y, Shaw DE, Martin-Fernandez ML. Needham SR, et al. Among authors: korovesis d. Nat Commun. 2016 Oct 31;7:13307. doi: 10.1038/ncomms13307. Nat Commun. 2016. PMID: 27796308 Free PMC article.
The architecture of EGFR's basal complexes reveals autoinhibition mechanisms in dimers and oligomers.
Zanetti-Domingues LC, Korovesis D, Needham SR, Tynan CJ, Sagawa S, Roberts SK, Kuzmanic A, Ortiz-Zapater E, Jain P, Roovers RC, Lajevardipour A, van Bergen En Henegouwen PMP, Santis G, Clayton AHA, Clarke DT, Gervasio FL, Shan Y, Shaw DE, Rolfe DJ, Parker PJ, Martin-Fernandez ML. Zanetti-Domingues LC, et al. Among authors: korovesis d. Nat Commun. 2018 Oct 18;9(1):4325. doi: 10.1038/s41467-018-06632-0. Nat Commun. 2018. PMID: 30337523 Free PMC article.
Stress-induced inflammation evoked by immunogenic cell death is blunted by the IRE1α kinase inhibitor KIRA6 through HSP60 targeting.
Rufo N, Korovesis D, Van Eygen S, Derua R, Garg AD, Finotello F, Vara-Perez M, Rožanc J, Dewaele M, de Witte PA, Alexopoulos LG, Janssens S, Sinkkonen L, Sauter T, Verhelst SHL, Agostinis P. Rufo N, et al. Among authors: korovesis d. Cell Death Differ. 2022 Jan;29(1):230-245. doi: 10.1038/s41418-021-00853-5. Epub 2021 Aug 27. Cell Death Differ. 2022. PMID: 34453119 Free PMC article.
Probes for Photoaffinity Labelling of Kinases.
Korovesis D, Beard HA, Mérillat C, Verhelst SHL. Korovesis D, et al. Chembiochem. 2021 Jul 1;22(13):2206-2218. doi: 10.1002/cbic.202000874. Epub 2021 Mar 30. Chembiochem. 2021. PMID: 33544409 Review.