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Polypeptide modulators of TRPV1 produce analgesia without hyperthermia.
Andreev YA, Kozlov SA, Korolkova YV, Dyachenko IA, Bondarenko DA, Skobtsov DI, Murashev AN, Kotova PD, Rogachevskaja OA, Kabanova NV, Kolesnikov SS, Grishin EV. Andreev YA, et al. Mar Drugs. 2013 Dec 16;11(12):5100-15. doi: 10.3390/md11125100. Mar Drugs. 2013. PMID: 24351908 Free PMC article.
TRPV1 activation power can switch an action mode for its polypeptide ligands.
Nikolaev MV, Dorofeeva NA, Komarova MS, Korolkova YV, Andreev YA, Mosharova IV, Grishin EV, Tikhonov DB, Kozlov SA. Nikolaev MV, et al. PLoS One. 2017 May 5;12(5):e0177077. doi: 10.1371/journal.pone.0177077. eCollection 2017. PLoS One. 2017. PMID: 28475608 Free PMC article.
Probing temperature and capsaicin-induced activation of TRPV1 channel via computationally guided point mutations in its pore and TRP domains.
Lubova KI, Chugunov AO, Volynsky PE, Trofimov Y, Korolkova YV, Mosharova IV, Kozlov SA, Andreev YA, Efremov RG. Lubova KI, et al. Among authors: korolkova yv. Int J Biol Macromol. 2020 May 1:S0141-8130(20)33110-X. doi: 10.1016/j.ijbiomac.2020.04.239. Online ahead of print. Int J Biol Macromol. 2020. PMID: 32371130
38 results