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Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA.
Xia Y, Zhou Y, Carter DS, McNeil MB, Choi W, Halladay J, Berry PW, Mao W, Hernandez V, O'Malley T, Korkegian A, Sunde B, Flint L, Woolhiser LK, Scherman MS, Gruppo V, Hastings C, Robertson GT, Ioerger TR, Sacchettini J, Tonge PJ, Lenaerts AJ, Parish T, Alley M. Xia Y, et al. Among authors: korkegian a. Life Sci Alliance. 2018 Jun 1;1(3):e201800025. doi: 10.26508/lsa.201800025. eCollection 2018 Jun. Life Sci Alliance. 2018. PMID: 30456352 Free PMC article.
A Target-Based Whole Cell Screen Approach To Identify Potential Inhibitors of Mycobacterium tuberculosis Signal Peptidase.
Bonnett SA, Ollinger J, Chandrasekera S, Florio S, O'Malley T, Files M, Jee JA, Ahn J, Casey A, Ovechkina Y, Roberts D, Korkegian A, Parish T. Bonnett SA, et al. Among authors: korkegian a. ACS Infect Dis. 2016 Dec 9;2(12):893-902. doi: 10.1021/acsinfecdis.6b00075. Epub 2016 Sep 19. ACS Infect Dis. 2016. PMID: 27642770 Free PMC article.
A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro.
Patel N, O'Malley T, Zhang YK, Xia Y, Sunde B, Flint L, Korkegian A, Ioerger TR, Sacchettini J, Alley MRK, Parish T. Patel N, et al. Among authors: korkegian a. Antimicrob Agents Chemother. 2017 Aug 24;61(9):e01205-17. doi: 10.1128/AAC.01205-17. Print 2017 Sep. Antimicrob Agents Chemother. 2017. PMID: 28674058 Free PMC article.
The 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis.
Korkegian A, O'Malley T, Xia Y, Zhou Y, Carter DS, Sunde B, Flint L, Thompson D, Ioerger TR, Sacchettini J, Alley MRK, Parish T. Korkegian A, et al. Tuberculosis (Edinb). 2018 Jan;108:96-98. doi: 10.1016/j.tube.2017.11.003. Epub 2017 Nov 7. Tuberculosis (Edinb). 2018. PMID: 29523334 Free PMC article.
Synthesis and biological evaluation of aryl-oxadiazoles as inhibitors of Mycobacterium tuberculosis.
Martinez-Grau MA, Valcarcel ICG, Early JV, Gessner RK, de Melo CS, de la Nava EMM, Korkegian A, Ovechkina Y, Flint L, Gravelle A, Cramer JW, Desai PV, Street LJ, Odingo J, Masquelin T, Chibale K, Parish T. Martinez-Grau MA, et al. Among authors: korkegian a. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1758-1764. doi: 10.1016/j.bmcl.2018.04.028. Epub 2018 Apr 13. Bioorg Med Chem Lett. 2018. PMID: 29680666 Free PMC article.
Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB.
Cleghorn LAT, Ray PC, Odingo J, Kumar A, Wescott H, Korkegian A, Masquelin T, Lopez Moure A, Wilson C, Davis S, Huggett M, Turner P, Smith A, Epemolu O, Zuccotto F, Riley J, Scullion P, Shishikura Y, Ferguson L, Rullas J, Guijarro L, Read KD, Green SR, Hipskind P, Parish T, Wyatt PG. Cleghorn LAT, et al. Among authors: korkegian a. J Med Chem. 2018 Aug 9;61(15):6592-6608. doi: 10.1021/acs.jmedchem.8b00172. Epub 2018 Jul 26. J Med Chem. 2018. PMID: 29944372 Free PMC article.
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