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Twelve Years of Drug Prioritization to Help Accelerate Disease Modification Trials in Parkinson's Disease: The International Linked Clinical Trials initiative.
Wyse RK, Isaacs T, Barker RA, Cookson MR, Dawson TM, Devos D, Dexter DT, Duffen J, Federoff H, Fiske B, Foltynie T, Fox S, Greenamyre JT, Kieburtz K, Kordower JH, Krainc D, Matthews H, Moore DJ, Mursaleen L, Schwarzschild MA, Stott SRW, Sulzer D, Svenningsson P, Tanner CM, Carroll C, Simon DK, Brundin P. Wyse RK, et al. Among authors: kordower jh. J Parkinsons Dis. 2024 Apr 5. doi: 10.3233/JPD-230363. Online ahead of print. J Parkinsons Dis. 2024. PMID: 38578902 Review.
Nigral-specific increase in ser31 phosphorylation compensates for tyrosine hydroxylase protein and nigrostriatal neuron loss: Implications for delaying parkinsonian signs.
Kasanga EA, Han Y, Shifflet MK, Navarrete W, McManus R, Parry C, Barahona A, Nejtek VA, Manfredsson FP, Kordower JH, Richardson JR, Salvatore MF. Kasanga EA, et al. Among authors: kordower jh. Exp Neurol. 2023 Oct;368:114509. doi: 10.1016/j.expneurol.2023.114509. Epub 2023 Aug 25. Exp Neurol. 2023. PMID: 37634696
Neither alpha-synuclein-preformed fibrils derived from patients with GBA1 mutations nor the host murine genotype significantly influence seeding efficacy in the mouse olfactory bulb.
Walton S, Fenyi A, Tittle T, Sidransky E, Pal G, Choi S, Melki R, Killinger BA, Kordower JH. Walton S, et al. Among authors: kordower jh. bioRxiv [Preprint]. 2023 Aug 25:2023.08.24.554646. doi: 10.1101/2023.08.24.554646. bioRxiv. 2023. PMID: 37662402 Free PMC article. Preprint.
Alpha-synuclein aggregates are phosphatase resistant.
Choi SG, Tittle T, Garcia-Prada D, Kordower JH, Melki R, Killinger BA. Choi SG, et al. Among authors: kordower jh. bioRxiv [Preprint]. 2024 Apr 9:2023.11.20.567854. doi: 10.1101/2023.11.20.567854. bioRxiv. 2024. PMID: 38645137 Free PMC article. Preprint.
361 results