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Switching the Switch: Ligand Induced Disulfide Formation in HDAC8.
Chemistry. 2020 Oct 15;26(58):13249-13255. doi: 10.1002/chem.202001712. Epub 2020 Sep 11.
Chemistry. 2020.
PMID: 32428298
Free PMC article.
The enzyme activity of histone deacetylase 8 is modulated by a redox-switch.
Jänsch N, Meyners C, Muth M, Kopranovic A, Witt O, Oehme I, Meyer-Almes FJ.
Jänsch N, et al. Among authors: kopranovic a.
Redox Biol. 2019 Jan;20:60-67. doi: 10.1016/j.redox.2018.09.013. Epub 2018 Sep 27.
Redox Biol. 2019.
PMID: 30292946
Free PMC article.
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Covalent inhibition of histone deacetylase 8 by 3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine.
Muth M, Jänsch N, Kopranovic A, Krämer A, Wössner N, Jung M, Kirschhöfer F, Brenner-Weiß G, Meyer-Almes FJ.
Muth M, et al. Among authors: kopranovic a.
Biochim Biophys Acta Gen Subj. 2019 Mar;1863(3):577-585. doi: 10.1016/j.bbagen.2019.01.001. Epub 2019 Jan 3.
Biochim Biophys Acta Gen Subj. 2019.
PMID: 30611847
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Electrophilic MiniFrags Revealed Unprecedented Binding Sites for Covalent HDAC8 Inhibitors.
Keeley AB, Kopranovic A, Di Lorenzo V, Ábrányi-Balogh P, Jänsch N, Lai LN, Petri L, Orgován Z, Pölöske D, Orlova A, Németh AG, Desczyk C, Imre T, Bajusz D, Moriggl R, Meyer-Almes FJ, Keserü GM.
Keeley AB, et al. Among authors: kopranovic a.
J Med Chem. 2024 Jan 11;67(1):572-585. doi: 10.1021/acs.jmedchem.3c01779. Epub 2023 Dec 19.
J Med Chem. 2024.
PMID: 38113354
Free PMC article.
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