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The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.
Canon J, Rex K, Saiki AY, Mohr C, Cooke K, Bagal D, Gaida K, Holt T, Knutson CG, Koppada N, Lanman BA, Werner J, Rapaport AS, San Miguel T, Ortiz R, Osgood T, Sun JR, Zhu X, McCarter JD, Volak LP, Houk BE, Fakih MG, O'Neil BH, Price TJ, Falchook GS, Desai J, Kuo J, Govindan R, Hong DS, Ouyang W, Henary H, Arvedson T, Cee VJ, Lipford JR. Canon J, et al. Among authors: koppada n. Nature. 2019 Nov;575(7781):217-223. doi: 10.1038/s41586-019-1694-1. Epub 2019 Oct 30. Nature. 2019. PMID: 31666701 Clinical Trial.
Pharmacokinetics and pharmacodynamics of DSTA4637A: A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus in mice.
Zhou C, Lehar S, Gutierrez J, Rosenberger CM, Ljumanovic N, Dinoso J, Koppada N, Hong K, Baruch A, Carrasco-Triguero M, Saad O, Mariathasan S, Kamath AV. Zhou C, et al. Among authors: koppada n. MAbs. 2016 Nov/Dec;8(8):1612-1619. doi: 10.1080/19420862.2016.1229722. Epub 2016 Sep 21. MAbs. 2016. PMID: 27653831 Free PMC article.
Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats.
Boswell CA, Mundo EE, Zhang C, Bumbaca D, Valle NR, Kozak KR, Fourie A, Chuh J, Koppada N, Saad O, Gill H, Shen BQ, Rubinfeld B, Tibbitts J, Kaur S, Theil FP, Fielder PJ, Khawli LA, Lin K. Boswell CA, et al. Among authors: koppada n. Bioconjug Chem. 2011 Oct 19;22(10):1994-2004. doi: 10.1021/bc200212a. Epub 2011 Oct 3. Bioconjug Chem. 2011. PMID: 21913715
Platform model describing pharmacokinetic properties of vc-MMAE antibody-drug conjugates.
Kågedal M, Gibiansky L, Xu J, Wang X, Samineni D, Chen SC, Lu D, Agarwal P, Wang B, Saad O, Koppada N, Fine BM, Jin JY, Girish S, Li C. Kågedal M, et al. Among authors: koppada n. J Pharmacokinet Pharmacodyn. 2017 Dec;44(6):537-548. doi: 10.1007/s10928-017-9544-y. Epub 2017 Sep 16. J Pharmacokinet Pharmacodyn. 2017. PMID: 28918591
Hypoxia Attenuates Trastuzumab Uptake and Trastuzumab-Emtansine (T-DM1) Cytotoxicity through Redistribution of Phosphorylated Caveolin-1.
Indira Chandran V, Månsson AS, Barbachowska M, Cerezo-Magaña M, Nodin B, Joshi B, Koppada N, Saad OM, Gluz O, Isaksson K, Borgquist S, Jirström K, Nabi IR, Jernström H, Belting M. Indira Chandran V, et al. Among authors: koppada n. Mol Cancer Res. 2020 Apr;18(4):644-656. doi: 10.1158/1541-7786.MCR-19-0856. Epub 2020 Jan 3. Mol Cancer Res. 2020. PMID: 31900313
An anti-B7-H4 antibody-drug conjugate for the treatment of breast cancer.
Leong SR, Liang WC, Wu Y, Crocker L, Cheng E, Sampath D, Ohri R, Raab H, Hass PE, Pham T, Firestein R, Li D, Schutten M, Stagg NJ, Ogasawara A, Koppada N, Roth L, Williams SP, Lee BC, Chalouni C, Peng I, DeVoss J, Tremayne J, Polakis P, Polson AG. Leong SR, et al. Among authors: koppada n. Mol Pharm. 2015 Jun 1;12(6):1717-29. doi: 10.1021/mp5007745. Epub 2015 Apr 23. Mol Pharm. 2015. PMID: 25853436