Kool J - Search Results

1

Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling.

Slagboom J, Otvos RA, Cardoso FC, Iyer J, Visser JC, van Doodewaerd BR, McCleary RJR, Niessen WMA, Somsen GW, Lewis RJ, Kini RM, Smit AB, Casewell NR, Kool J. Slagboom J, et al. Among authors: kool j. Toxicon. 2018 Jun 15;148:213-222. doi: 10.1016/j.toxicon.2018.04.022. Epub 2018 May 4. Toxicon. 2018. PMID: 29730150 Free article.

2

On-line formation, separation, and estrogen receptor affinity screening of cytochrome P450-derived metabolites of selective estrogen receptor modulators.

van Liempd SM, Kool J, Niessen WM, van Elswijk DE, Irth H, Vermeulen NP. van Liempd SM, et al. Among authors: kool j. Drug Metab Dispos. 2006 Sep;34(9):1640-9. doi: 10.1124/dmd.106.010355. Epub 2006 Jun 21. Drug Metab Dispos. 2006. PMID: 16790557

3

Online screening of homogeneous catalyst performance using reaction detection mass spectrometry.

Martha CT, Elders N, Krabbe JG, Kool J, Niessen WM, Orru RV, Irth H. Martha CT, et al. Among authors: kool j. Anal Chem. 2008 Sep 15;80(18):7121-7. doi: 10.1021/ac801003h. Epub 2008 Aug 13. Anal Chem. 2008. PMID: 18698801

4

Development of a selective ESI-MS derivatization reagent: synthesis and optimization for the analysis of aldehydes in biological mixtures.

Eggink M, Wijtmans M, Ekkebus R, Lingeman H, de Esch IJ, Kool J, Niessen WM, Irth H. Eggink M, et al. Among authors: kool j. Anal Chem. 2008 Dec 1;80(23):9042-51. doi: 10.1021/ac801429w. Anal Chem. 2008. PMID: 19551932

5

Development of an on-line weak-cation exchange liquid chromatography-tandem mass spectrometric method for screening aldehyde products in biological matrices.

Eggink M, Charret S, Wijtmans M, Lingeman H, Kool J, Niessen WM, Irth H. Eggink M, et al. Among authors: kool j. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Dec 1;877(31):3937-45. doi: 10.1016/j.jchromb.2009.09.043. Epub 2009 Oct 14. J Chromatogr B Analyt Technol Biomed Life Sci. 2009. PMID: 19880357

6

Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR.

de Vlieger JS, Kolkman AJ, Ampt KA, Commandeur JN, Vermeulen NP, Kool J, Wijmenga SS, Niessen WM, Irth H, Honing M. de Vlieger JS, et al. Among authors: kool j. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Mar 1;878(7-8):667-74. doi: 10.1016/j.jchromb.2010.01.035. Epub 2010 Jan 29. J Chromatogr B Analyt Technol Biomed Life Sci. 2010. PMID: 20149764

7

Targeted LC-MS derivatization for aldehydes and carboxylic acids with a new derivatization agent 4-APEBA.

Eggink M, Wijtmans M, Kretschmer A, Kool J, Lingeman H, de Esch IJ, Niessen WM, Irth H. Eggink M, et al. Among authors: kool j. Anal Bioanal Chem. 2010 May;397(2):665-75. doi: 10.1007/s00216-010-3575-1. Epub 2010 Mar 19. Anal Bioanal Chem. 2010. PMID: 20238107 Free PMC article.

8

High throughput screening methodologies classified for major drug target classes according to target signaling pathways.

Kool J, Lingeman H, Niessen W, Irth H. Kool J, et al. Comb Chem High Throughput Screen. 2010 Jul;13(6):548-61. doi: 10.2174/138620710791515815. Comb Chem High Throughput Screen. 2010. PMID: 20429869 Review.

9

Production and on-line acetylcholinesterase bioactivity profiling of chemical and biological degradation products of tacrine.

Marques LA, Kool J, de Kanter F, Lingeman H, Niessen W, Irth H. Marques LA, et al. Among authors: kool j. J Pharm Biomed Anal. 2010 Nov 2;53(3):609-16. doi: 10.1016/j.jpba.2010.04.015. Epub 2010 Apr 18. J Pharm Biomed Anal. 2010. PMID: 20466502

10

Online fluorescence enhancement assay for the acetylcholine binding protein with parallel mass spectrometric identification.

Kool J, de Kloe GE, Bruyneel B, de Vlieger JS, Retra K, Wijtmans M, van Elk R, Smit AB, Leurs R, Lingeman H, de Esch IJ, Irth H. Kool J, et al. J Med Chem. 2010 Jun 24;53(12):4720-30. doi: 10.1021/jm100230k. J Med Chem. 2010. PMID: 20518527

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